Document Detail

Colchicine reduces postoperative atrial fibrillation: results of the Colchicine for the Prevention of the Postpericardiotomy Syndrome (COPPS) atrial fibrillation substudy.
MedLine Citation:
PMID:  22090167     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Inflammation and pericarditis may be contributing factors for postoperative atrial fibrillation (POAF), and both are potentially affected by antiinflammatory drugs and colchicine, which has been shown to be safe and efficacious for the prevention of pericarditis and the postpericardiotomy syndrome (PPS). The aim of the Colchicine for the Prevention of the Post-Pericardiotomy Syndrome (COPPS) POAF substudy was to test the efficacy and safety of colchicine for the prevention of POAF after cardiac surgery.
METHODS AND RESULTS: The COPPS POAF substudy included 336 patients (mean age, 65.7±12.3 years; 69% male) of the COPPS trial, a multicenter, double-blind, randomized trial. Substudy patients were in sinus rhythm before starting the intervention (placebo/colchicine 1.0 mg twice daily starting on postoperative day 3 followed by a maintenance dose of 0.5 mg twice daily for 1 month in patients ≥70 kg, halved doses for patients <70 kg or intolerant to the highest dose). The substudy primary end point was the incidence of POAF on intervention at 1 month. Despite well-balanced baseline characteristics, patients on colchicine had a reduced incidence of POAF (12.0% versus 22.0%, respectively; P=0.021; relative risk reduction, 45%; number needed to treat, 11) with a shorter in-hospital stay (9.4±3.7 versus 10.3±4.3 days; P=0.040) and rehabilitation stay (12.1±6.1 versus 13.9±6.5 days; P=0.009). Side effects were similar in the study groups.
CONCLUSION: Colchicine seems safe and efficacious in the reduction of POAF with the potentiality of halving the complication and reducing the hospital stay.
Massimo Imazio; Antonio Brucato; Paolo Ferrazzi; Maria Elena Rovere; Anna Gandino; Roberto Cemin; Stefania Ferrua; Riccardo Belli; Silvia Maestroni; Caterina Simon; Edoardo Zingarelli; Alberto Barosi; Fabrizio Sansone; Davide Patrini; Ettore Vitali; Rita Trinchero; David H Spodick; Yehuda Adler;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2011-11-16
Journal Detail:
Title:  Circulation     Volume:  124     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-22     Completed Date:  2012-01-12     Revised Date:  2012-03-01    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2290-5     Citation Subset:  AIM; IM    
Cardiology Department, Maria Vittoria Hospital, Via Cibrario 72, Turin, Italy.
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MeSH Terms
Anti-Arrhythmia Agents / adverse effects,  therapeutic use*
Atrial Fibrillation / epidemiology*,  physiopathology,  prevention & control*
Cardiac Surgical Procedures*
Colchicine / adverse effects,  therapeutic use*
Dose-Response Relationship, Drug
Double-Blind Method
Kaplan-Meier Estimate
Length of Stay
Middle Aged
Postoperative Period
Prospective Studies
Treatment Outcome
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 64-86-8/Colchicine
M Imazio / ; A Chinaglia / ; B Demichelis / ; S Ierna / ; S Maestroni / ; C Simon / ; D Cumetti / ; P Ferrazzi / ; M E Rovere / ; E Zingarelli / ; F Sansone / ; A Gandino / ; A Barosi / ; D Patrini / ; E Vitali / ; R Cemin / ; S Ferrua / ; M R Conte /
Comment In:
Nat Rev Cardiol. 2012 Feb;9(2):67   [PMID:  22143081 ]
Nat Rev Cardiol. 2012 Feb;9(2):67   [PMID:  22143082 ]
Circulation. 2011 Nov 22;124(21):2281-2   [PMID:  22105193 ]

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