Document Detail


Col2-GFP reporter mouse--a new tool to study skeletal development.
MedLine Citation:
PMID:  11891675     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transgenic mice were generated that harbor a Col2-GFP reporter that marks chondrocytes and their immediate precursors during skeletal development. Cells engaged in chondrogenesis were identified by conventional fluorescence microscopy and confocal optical sectioning within their native environments in live embryos and in thick tissue slices. The use of these mice offers a novel approach for studying the role of chondrocytes in skeletal development.
Authors:
J Y Cho; T D Grant; G P Lunstrum; W A Horton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of medical genetics     Volume:  106     ISSN:  0148-7299     ISO Abbreviation:  Am. J. Med. Genet.     Publication Date:  2001  
Date Detail:
Created Date:  2002-03-13     Completed Date:  2002-06-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708900     Medline TA:  Am J Med Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  251-3     Citation Subset:  IM    
Affiliation:
Research Center, Shriners Hospital for Children, Portland, OR 97201, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Development*
Chondrocytes / physiology
Collagen Type II / genetics*,  physiology
Disease Models, Animal*
Genes, Reporter / physiology
Green Fluorescent Proteins
Luminescent Proteins / genetics*,  physiology
Mice
Mice, Transgenic
Organ Specificity / physiology
Chemical
Reg. No./Substance:
0/Collagen Type II; 0/Luminescent Proteins; 147336-22-9/Green Fluorescent Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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