| Coincidence of counter-antigonadal and counter-antithyroid action of melatonin administration via the drinking water in male golden hamsters. | |
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MedLine Citation:
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PMID: 6700372 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Administration of melatonin via the drinking water prevented the gonadal involution and the thyroid hormone depletion normally observed in blinded hamsters. Ten weeks after blinding male hamsters had plasma thyroxin levels that were 57% of controls and testis weights that were 8% of controls. Administration of melatonin (80 microgram melatonin/ml drinking water) to blinded hamsters restored thyroxin levels to 86% of controls and testis weights to 93% of controls. Dose response data showed that as little as 1.25 microgram (approximately 10 microgram/hamster/day) produced a significant effect on testis weight, whereas the lowest dose required to produce a significant increase in thyroxin levels was 10 microgram/ml. The coincidence of counter-antigonadal and counter-antithyroid actions of melatonin suggests a single site of action. |
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Authors:
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J Vriend; F P Gibbs |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Life sciences Volume: 34 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1984 Feb |
Date Detail:
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Created Date: 1984-03-26 Completed Date: 1984-03-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 617-23 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blindness / blood, physiopathology* Cricetinae Dose-Response Relationship, Drug Drinking Male Melatonin / administration & dosage, pharmacology* Mesocricetus Organ Size / drug effects Pineal Gland / surgery Testis / drug effects* Thyroxine / blood* |
| Chemical | |
Reg. No./Substance:
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73-31-4/Melatonin; 7488-70-2/Thyroxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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