Document Detail


Cohort profile: the Lothian Birth Cohorts of 1921 and 1936.
MedLine Citation:
PMID:  22253310     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This cohort profile describes the origins, tracing, recruitment, testing and follow-up of the University of Edinburgh-based Lothian Birth Cohorts of 1921 (LBC1921; N = 550) and 1936 (LBC1936; N = 1091). The participants undertook a general intelligence test at age 11 years and were recruited for these cohorts at mean ages of 79 (LBC1921) and 70 (LBC1936). The LBC1921 have been examined at mean ages of 79, 83, 87 and 90 years. The LBC1936 have been examined at mean ages of 70 and 73 years, and are being seen at 76 years. Both samples have an emphasis on the ageing of cognitive functions as outcomes. As they have childhood intelligence test scores, the cohorts' data have been used to search for determinants of lifetime cognitive changes, and also cognitive change within old age. The cohorts' outcomes also include a range of physical and psycho-social aspects of well-being in old age. Both cohorts have a wide range of variables: genome-wide genotyping, demographics, psycho-social and lifestyle factors, cognitive functions, medical history and examination, and biomarkers (from blood and urine). The LBC1936 participants also have a detailed structural magnetic resonance imaging (MRI) brain scan. A range of scientific findings is described, to illustrate the possible uses of the cohorts.
Authors:
Ian J Deary; Alan J Gow; Alison Pattie; John M Starr
Publication Detail:
Type:  Historical Article; Journal Article     Date:  2011-12-14
Journal Detail:
Title:  International journal of epidemiology     Volume:  41     ISSN:  1464-3685     ISO Abbreviation:  Int J Epidemiol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-01-03     Completed Date:  2013-06-10     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  7802871     Medline TA:  Int J Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1576-84     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Aging / physiology*
Biological Markers
Child
Cognition*
Cohort Studies
Female
Health Behavior
Health Status
History, 20th Century
Humans
Intelligence*
Life Style
Magnetic Resonance Imaging
Male
Scotland / epidemiology
Socioeconomic Factors
Grant Support
ID/Acronym/Agency:
G0701120//Medical Research Council
Chemical
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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