Document Detail

Coherent hemodynamics spectroscopy in a single step.
MedLine Citation:
PMID:  25360359     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Coherent Hemodynamics Spectroscopy (CHS) is a technique based on inducing cerebral hemodynamic oscillations at multiple frequencies, measuring them with near-infrared spectroscopy (NIRS), and analyzing them with a hemodynamic model to obtain physiological information such as blood transit times in the microvasculature and the autoregulation cutoff frequency. We have previously demonstrated that such oscillations can be induced one frequency at a time. Here we demonstrate that CHS can be performed by a single inflation of two pneumatic thigh cuffs (duration: 2 min; pressure: 200 mmHg), whose sudden release produces a step response in systemic arterial blood pressure that lasts for ~20 s and induces cerebral hemodynamics that contain all the frequency information necessary for CHS. Following a validation study on simulated data, we performed measurements on human subjects with this new method based on a single occlusion/release of the thigh cuffs and with the previous method based on sequential sets of cyclic inflation/deflation one frequency at a time, and demonstrated that the two methods yield the same CHS spectra and the same physiological parameters (within measurement errors). The advantages of the new method presented here are that CHS spectra cover the entire bandwidth of the induced hemodynamic response, they are measured over ~20 s thus better satisfying the requirement of time invariance of physiological conditions, and they can be measured every ~2.5 min thus achieving finer temporal sampling in monitoring applications.
Jana M Kainerstorfer; Angelo Sassaroli; Sergio Fantini
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Publication Detail:
Type:  Journal Article     Date:  2014-09-04
Journal Detail:
Title:  Biomedical optics express     Volume:  5     ISSN:  2156-7085     ISO Abbreviation:  Biomed Opt Express     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-31     Completed Date:  2014-10-31     Revised Date:  2014-11-03    
Medline Journal Info:
Nlm Unique ID:  101540630     Medline TA:  Biomed Opt Express     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3403-16     Citation Subset:  -    
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