Document Detail


Coherent Raman scanning fiber endoscopy.
MedLine Citation:
PMID:  21725423     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Coherent Raman scattering methods allow for label-free imaging of tissue with chemical contrast and high spatial and temporal resolution. However, their imaging depth in scattering tissue is limited to less than 1 mm, requiring the development of endoscopes to obtain images deep inside the body. Here, we describe a coherent Raman endoscope that provides stimulated Raman scattering images at seven frames per second using a miniaturized fiber scanner, a custom-designed objective lens, and an optimized scheme for collection of scattered light from the tissue. We characterize the system and demonstrate chemical selectivity in mouse tissue images.
Authors:
Brian G Saar; Richard S Johnston; Christian W Freudiger; X Sunney Xie; Eric J Seibel
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Optics letters     Volume:  36     ISSN:  1539-4794     ISO Abbreviation:  Opt Lett     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-04     Completed Date:  2011-11-22     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  7708433     Medline TA:  Opt Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2396-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Endoscopy / methods*
Mice
Skin
Spectrum Analysis, Raman / methods*
Grant Support
ID/Acronym/Agency:
1R01EB010244-01/EB/NIBIB NIH HHS; R21 EB012666/EB/NIBIB NIH HHS; R21 EB012666/EB/NIBIB NIH HHS; R21 EB012666-01/EB/NIBIB NIH HHS; R33 CA 094303/CA/NCI NIH HHS
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