| Cohabitation with a sick cage mate: consequences on behavior and on ehrlich tumor growth. | |
| | |
MedLine Citation:
|
PMID: 14557679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The present study analyzed the effects of cohabitation for 11 days with a sick cage mate on behavior and Ehrlich tumor growth in mice. Pairs of female mice were divided into one control and one experimental group. One mouse of each control pair was kept undisturbed and called 'healthy companion' (HC). One animal of each experimental pair of mice was inoculated (i.p.) with 5 x 10(6) Ehrlich tumor cells, and the other, the object of this study, was called 'sick companion' (SC). The SC mice presented: (1) increased activity in an open field, (2) increased number of entries and of movements within the plus-maze open arms, (3) similar levels of plus-maze closed-arm exploration, (4) a decrease in the exploratory activity in a hole board, (5) a decrease in the number of white but not red blood cells, and (6) similar corticosterone serum levels. Eleven days after cohabitation with a conspecific, HC and SC mice were injected with 5 x10(6) Ehrlich tumor cells. Results showed that SC animals presented decreased resistance to the ascitic form of the Ehrlich tumor. The observed data provide experimental evidence that psychosocial stress induced by cohabitation with a sick cage mate changed at the same time some behavioral and physiological parameters, and decreased resistance to Ehrlich tumor. These data are discussed in the light of a possible neuroimmune system interaction. |
| | |
Authors:
|
Maria Sílvia F A Morgulis; Daniel Stankevicius; Luiz Carlos Sá-Rocha; João Palermo-Neto |
Related Documents
:
|
16428079 - Tumor-induced thymic involution via inhibition of il-7r alpha and its jak-stat signalin... 6539929 - The mutagenicity of alpha particles in ehrlich ascites tumor cells. 7245839 - The effect of glucosone on the proliferation and energy metabolism of in vitro grown eh... 280709 - Cytochemical study on uptake of exogenous peroxidase by vx2 carcinoma cells transplante... 18267359 - Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors. 22066019 - Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthot... 15523089 - Synergistic antitumor activity of histamine plus melphalan in isolated limb perfusion: ... 22614559 - Inflammatory myofibroblastic tumor of the nose and paranasal sinuses masquerading as a ... 15489959 - Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Neuroimmunomodulation Volume: 11 ISSN: 1021-7401 ISO Abbreviation: Neuroimmunomodulation Publication Date: 2004 |
Date Detail:
|
Created Date: 2003-10-14 Completed Date: 2004-03-24 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9422763 Medline TA: Neuroimmunomodulation Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 49-57 Citation Subset: IM |
Copyright Information:
|
Copyright 2004 S. Karger AG, Basel |
Affiliation:
|
Department of Pathology, School of Veterinary Medicine, University of São Paulo, São Paulo, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Ascites Behavior, Animal* Carcinoma, Ehrlich Tumor / immunology*, pathology, psychology* Female Housing, Animal Mice Neoplasm Transplantation Neuroimmunomodulation / physiology* Sick Role Social Behavior |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inhibition of decrease in natural killer cell activity in repeatedly restraint-stressed mice by a bi...
Next Document: The sympathetic control of blood supply is different in the spleen and lymph nodes.