Document Detail


Cognitive reserve and brain volumes in pediatric acute lymphoblastic leukemia.
MedLine Citation:
PMID:  20814845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute lymphoblastic leukemia (ALL) is associated with long-term, progressive cognitive deficits and white matter injury. We measured global and regional white and gray matter as well as cognitive function and examined relationships between these variables and cognitive reserve, as indicated by maternal education level, in 28 young survivors of ALL and 31 healthy controls. Results indicated significantly reduced white matter volumes and cognitive testing scores in the ALL group compared to controls. Maternal education was inversely related to both global and regional white matter and directly related to gray matter in ALL and was directly related to both gray and white matter in controls, consistent with the cognitive reserve hypothesis. Cognitive performance was associated with different brain regions in ALL compared to controls. Maternal education was significantly positively correlated with working and verbal memory in ALL as well as processing speed and verbal memory in controls, improving models of cognitive outcome over medical and/or demographic predictors. Our findings suggest that cognitive reserve may be an important factor in brain injury and cognitive outcome in ALL. Additionally, children with ALL may experience some neural reorganization related to cognitive outcome.
Authors:
Shelli R Kesler; Hiroko Tanaka; Della Koovakkattu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Brain imaging and behavior     Volume:  4     ISSN:  1931-7565     ISO Abbreviation:  Brain Imaging Behav     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-10-05     Completed Date:  2011-03-03     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  101300405     Medline TA:  Brain Imaging Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  256-69     Citation Subset:  IM    
Affiliation:
Department of Psychiatry and Behavioral Sciences, Neuropsychology and Neurorehabilitation Laboratory, Stanford University School of Medicine, Palo Alto, CA 94305, USA. skesler@stanford.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antimetabolites, Antineoplastic / therapeutic use
Brain / pathology*
Child
Child, Preschool
Cognition / physiology
Cognitive Reserve / physiology*
Female
Humans
Image Processing, Computer-Assisted
Injections, Spinal
Magnetic Resonance Imaging
Male
Methotrexate / therapeutic use
Neuropsychological Tests
Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology*,  psychology*
Survivors
Treatment Outcome
Young Adult
Grant Support
ID/Acronym/Agency:
K07 CA134639/CA/NCI NIH HHS; K07 CA134639-01A1/CA/NCI NIH HHS; K07 CA134639-03/CA/NCI NIH HHS; R24 HD050836/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 59-05-2/Methotrexate
Comments/Corrections

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