| Cognitive reserve and brain volumes in pediatric acute lymphoblastic leukemia. | |
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MedLine Citation:
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PMID: 20814845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute lymphoblastic leukemia (ALL) is associated with long-term, progressive cognitive deficits and white matter injury. We measured global and regional white and gray matter as well as cognitive function and examined relationships between these variables and cognitive reserve, as indicated by maternal education level, in 28 young survivors of ALL and 31 healthy controls. Results indicated significantly reduced white matter volumes and cognitive testing scores in the ALL group compared to controls. Maternal education was inversely related to both global and regional white matter and directly related to gray matter in ALL and was directly related to both gray and white matter in controls, consistent with the cognitive reserve hypothesis. Cognitive performance was associated with different brain regions in ALL compared to controls. Maternal education was significantly positively correlated with working and verbal memory in ALL as well as processing speed and verbal memory in controls, improving models of cognitive outcome over medical and/or demographic predictors. Our findings suggest that cognitive reserve may be an important factor in brain injury and cognitive outcome in ALL. Additionally, children with ALL may experience some neural reorganization related to cognitive outcome. |
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Authors:
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Shelli R Kesler; Hiroko Tanaka; Della Koovakkattu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Brain imaging and behavior Volume: 4 ISSN: 1931-7565 ISO Abbreviation: Brain Imaging Behav Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-10-05 Completed Date: 2011-03-03 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 101300405 Medline TA: Brain Imaging Behav Country: United States |
Other Details:
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Languages: eng Pagination: 256-69 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Behavioral Sciences, Neuropsychology and Neurorehabilitation Laboratory, Stanford University School of Medicine, Palo Alto, CA 94305, USA. skesler@stanford.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antimetabolites, Antineoplastic / therapeutic use Brain / pathology* Child Child, Preschool Cognition / physiology Cognitive Reserve / physiology* Female Humans Image Processing, Computer-Assisted Injections, Spinal Magnetic Resonance Imaging Male Methotrexate / therapeutic use Neuropsychological Tests Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology*, psychology* Survivors Treatment Outcome Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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K07 CA134639/CA/NCI NIH HHS; K07 CA134639-01A1/CA/NCI NIH HHS; K07 CA134639-03/CA/NCI NIH HHS; R24 HD050836/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antimetabolites, Antineoplastic; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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