| Cognitive rehabilitation combined with drug treatment in Alzheimer's disease patients: a pilot study. | |
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MedLine Citation:
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PMID: 16323385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the efficacy of cognitive rehabilitation combined with acetylcholinesterase inhibitor (AChE-I) treatment in patients with mild Alzheimer's disease and their relatives. METHOD: Thirteen patients with mild Alzheimer's disease treated with rivastigmine 6-12 mg/day for more than two months started cognitive rehabilitation training. Before and after the cognitive rehabilitation training patients were assessed through cognitive tests, activities of daily living scale, neuropsychological battery and scales to evaluate caregivers' depressive and anxiety symptoms. Six patients were randomized to a combined treatment group (AChE-I plus cognitive rehabilitation and caregiver support) and seven patients to a control group (AChE-I only) and followed up for five months. RESULTS: Mini-Mental State Examination (MMSE) scores (p = 0.047) and backward digit span scores (p = 0.018) were significantly different between the groups on follow-up. The combined treatment group showed a better positive treatment effect on cognitive and neuropsychological tests applied to patients and reduction of psychiatric symptoms was observed in their caregivers (nonsignificant). CONCLUSION: Cognitive rehabilitation associated with AChE-I treatment can potentially be useful to stabilize or improve cognitive and functional performance of patients with mild Alzheimer's disease and can reduce caregivers' psychiatric symptoms. |
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Authors:
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C?ssio M C Bottino; Isabel A M Carvalho; Ana Maria M A Alvarez; Renata Avila; Patr?cia R Zukauskas; Sonia E Z Bustamante; Fl?via C Andrade; S?rgio R Hototian; Fabiana Saffi; Candida H P C?margo |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical rehabilitation Volume: 19 ISSN: 0269-2155 ISO Abbreviation: Clin Rehabil Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-05 Completed Date: 2006-01-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8802181 Medline TA: Clin Rehabil Country: England |
Other Details:
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Languages: eng Pagination: 861-9 Citation Subset: IM |
Affiliation:
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Old Age Research Group (PROTER), Department and Institute of Psychiatry, University of S?o Paulo, S?o Paulo, Brazil. cbottino@usp.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Activities of Daily Living Aged Aged, 80 and over Alzheimer Disease / drug therapy*, rehabilitation* Anxiety Caregivers / psychology Cholinesterase Inhibitors / therapeutic use* Cognition Disorders / etiology, therapy* Cognitive Therapy* Depression Female Humans Male Mental Status Schedule Middle Aged Phenylcarbamates / therapeutic use* Pilot Projects Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Cholinesterase Inhibitors; 0/Phenylcarbamates; 123441-03-2/rivastigmine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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