| Cognitive reduction in presenile dementia related to regional abnormalities of the cerebral blood flow. | |
MedLine Citation:
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PMID: 1252685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fifty-five patients with presenile dementia were examined. There were 28 women and 27 men, and the mean age was 59 and 56 years respectively at the time of the study. A large series of psychometric tests was used, and with the aid of age-matched non-demented controls five significantly different cognitive reduction groups could be identified. In the demented patients the regional cerebral blood flow (rCBF) was determined with an eight-detector or 32-detector equipment. There was a rough proportionality between the cognitive reduction and a decrease of the cerebral blood flow (especially the flow in the grey matter). In addition, certain regional flow abnormalities correlated with specific cognitive functions in a manner resembling the cognitive defects found in focal brain lesions in the same region. Thus, patients who showed only memory disturbances demonstrated a focal flow reduction in the temporal region. More severely affected patients, with reduction of verbal abilities and signs of agnosia, showed very low flows in occipito-temporo-parietal parts of the hemisphere. The results offer a principal confirmation of the dynamic field theory concerning the functional organization of the cerebral cortex. |
Authors:
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B O Hagberg; D H Ingvar |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The British journal of psychiatry : the journal of mental science Volume: 128 ISSN: 0007-1250 ISO Abbreviation: Br J Psychiatry Publication Date: 1976 Mar |
Date Detail:
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Created Date: 1976-06-02 Completed Date: 1976-06-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0342367 Medline TA: Br J Psychiatry Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 209-22 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Agnosia / etiology Carbon Dioxide / blood Cerebral Cortex / blood supply Cognition Disorders / etiology* Dementia / complications* Female Humans Male Memory Disorders / etiology Middle Aged Neuropsychological Tests Occipital Lobe / blood supply Parietal Lobe / blood supply Partial Pressure Reaction Time Regional Blood Flow Space Perception Speech Disorders / etiology Temporal Lobe / blood supply |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
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