Document Detail

Cognitive reduction in presenile dementia related to regional abnormalities of the cerebral blood flow.
MedLine Citation:
PMID:  1252685     Owner:  NLM     Status:  MEDLINE    
Fifty-five patients with presenile dementia were examined. There were 28 women and 27 men, and the mean age was 59 and 56 years respectively at the time of the study. A large series of psychometric tests was used, and with the aid of age-matched non-demented controls five significantly different cognitive reduction groups could be identified. In the demented patients the regional cerebral blood flow (rCBF) was determined with an eight-detector or 32-detector equipment. There was a rough proportionality between the cognitive reduction and a decrease of the cerebral blood flow (especially the flow in the grey matter). In addition, certain regional flow abnormalities correlated with specific cognitive functions in a manner resembling the cognitive defects found in focal brain lesions in the same region. Thus, patients who showed only memory disturbances demonstrated a focal flow reduction in the temporal region. More severely affected patients, with reduction of verbal abilities and signs of agnosia, showed very low flows in occipito-temporo-parietal parts of the hemisphere. The results offer a principal confirmation of the dynamic field theory concerning the functional organization of the cerebral cortex.
B O Hagberg; D H Ingvar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  128     ISSN:  0007-1250     ISO Abbreviation:  Br J Psychiatry     Publication Date:  1976 Mar 
Date Detail:
Created Date:  1976-06-02     Completed Date:  1976-06-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  209-22     Citation Subset:  IM    
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MeSH Terms
Age Factors
Agnosia / etiology
Carbon Dioxide / blood
Cerebral Cortex / blood supply
Cognition Disorders / etiology*
Dementia / complications*
Memory Disorders / etiology
Middle Aged
Neuropsychological Tests
Occipital Lobe / blood supply
Parietal Lobe / blood supply
Partial Pressure
Reaction Time
Regional Blood Flow
Space Perception
Speech Disorders / etiology
Temporal Lobe / blood supply
Reg. No./Substance:
124-38-9/Carbon Dioxide

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