Document Detail


Cognitive loss and recovery in long-term alcohol abusers.
MedLine Citation:
PMID:  6838323     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The nature of the memory and visuospatial defects associated with chronic alcoholism, and the recovery of these functions, were investigated in a large group of alcoholic men and well-matched nonalcoholic controls. Both young and old alcoholics displayed significant impairments on tasks requiring the learning of novel associations and the holding of information in memory over longer delay intervals. The recovery of cognitive skills was found to depend on the length of abstinence and the particular behavioral functions examined. Whereas psychomotor skills and short-term memory improved significantly with prolonged abstinence, long-term memory was impaired even after seven years of continuous sobriety. We propose that recovery of short-term memory reflects reestablishment of cortical functioning, while the persistent long-term memory defect indicates more permanent damage to diencephalic structures.
Authors:
J Brandt; N Butters; C Ryan; R Bayog
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of general psychiatry     Volume:  40     ISSN:  0003-990X     ISO Abbreviation:  Arch. Gen. Psychiatry     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372435     Medline TA:  Arch Gen Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  435-42     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Alcohol Drinking
Alcoholism / physiopathology,  psychology*,  rehabilitation
Cerebral Cortex / physiopathology
Cognition Disorders / physiopathology,  psychology*
Diencephalon / physiopathology
Humans
Male
Memory Disorders / physiopathology,  psychology
Memory, Short-Term
Middle Aged
Paired-Associate Learning
Psychomotor Performance
Grant Support
ID/Acronym/Agency:
AA-00187/AA/NIAAA NIH HHS; F31-MH 08148-01/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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