| Cognitive impairments in multiple system atrophy: MSA-C vs MSA-P. | |
| | |
MedLine Citation:
|
PMID: 18413566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: We evaluated comprehensive neuropsychological tests and regional brain blood flow to compare cognitive dysfunction between two types of multiple system atrophy: predominant cerebellar ataxia (MSA-C) and predominant parkinsonism (MSA-P). METHODS: Twenty-one patients with MSA-C, 14 patients with MSA-P, and 21 age- and education-matched control subjects were subjected to neuropsychological tests and SPECT. The neuropsychological tests examined general cognition, verbal and visual memory, working memory, visuospatial and constructional ability, language, executive function, depression, and anxiety, while SPECT analysis examined brain perfusion. RESULTS: Patients with MSA-P showed severe involvement of visuospatial and constructional function, verbal fluency, and executive function compared with control subjects. Patients with MSA-C showed involvement only in visuospatial and constructional function compared with control subjects and a milder degree of involvement compared with patients with MSA-P. Patients with MSA-P tended toward a wide and severe impairment in cognitive function compared with patients with MSA-C. In addition, neuropsychological impairment in patients with MSA-P was significantly correlated with a decrease in prefrontal perfusion. This significant relation was not correlated to other factors such as age, education, and severity of cerebellar ataxia and parkinsonism, which are relevant factors associated with cognitive performance. CONCLUSIONS: Patients with multiple system atrophy-parkinsonism show more severe and more widespread cognitive dysfunctions than patients with multiple system atrophy-cerebellar ataxia. Our results also indicate that cognitive dysfunction in patients with multiple system atrophy-parkinsonism may be associated with prefrontal involvement. |
| | |
Authors:
|
Y Kawai; M Suenaga; A Takeda; M Ito; H Watanabe; F Tanaka; K Kato; H Fukatsu; S Naganawa; T Kato; K Ito; G Sobue |
Related Documents
:
|
21834936 - Response to a selective cox-2 inhibitor in patients with urticaria/angioedema induced b... 8502376 - Impaired cognitive shifting in parkinsonian patients on anticholinergic therapy. 2926426 - Finger tremor in parkinson's disease. 10405696 - Detection of preclinical parkinson disease in at-risk family members with use of [123i]... 18671636 - Reversible monoparesis following decompressive hemicraniectomy for traumatic brain injury. 20827556 - Tau and 14-3-3 of genetic and sporadic creutzfeldt-jakob disease patients in israel. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Neurology Volume: 70 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2008 Apr |
Date Detail:
|
Created Date: 2008-04-16 Completed Date: 2008-05-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
|
Languages: eng Pagination: 1390-6 Citation Subset: AIM; IM |
Affiliation:
|
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Cerebellar Ataxia / complications, psychology*, radionuclide imaging Cognition Disorders / complications, psychology*, radionuclide imaging Female Humans Male Mental Status Schedule Middle Aged Multiple System Atrophy / complications, psychology*, radionuclide imaging Neuropsychological Tests Parkinson Disease / complications, psychology*, radionuclide imaging Tomography, Emission-Computed, Single-Photon / methods |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Association of beta1-adrenergic receptor genetic polymorphism with mental stress-induced myocardial ...
Next Document: Parkinson disease and risk of mortality: a prospective comorbidity-matched cohort study.