Document Detail


Cognitive impairment in the septic brain.
MedLine Citation:
PMID:  19534717     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Sepsis is a major disease entity with important clinical implications. It is associated with a high mortality rate in humans. Recently, several studies have demonstrated that Intensive Care Unit survivors present long-term cognitive impairment, including alterations in memory, attention, concentration and/or global loss of cognitive function. The pathogenesis of septic encephalopathy and cognitive impairment are still poorly known and further understanding of these processes is necessary for the development of effective preventive and therapeutic interventions. Here we discuss the clinical presentation and underlying pathophysiology of the encephalopathy and neurobiology of the cognitive impairment associated with sepsis.
Authors:
Clarissa M Comim; Leandra C Constantino; Tatiana Barichello; Emílio L Streck; João Quevedo; Felipe Dal-Pizzol
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-08-01
Journal Detail:
Title:  Current neurovascular research     Volume:  6     ISSN:  1875-5739     ISO Abbreviation:  -     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101208439     Medline TA:  Curr Neurovasc Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  194-203     Citation Subset:  IM    
Affiliation:
Laboratório de Neurociências and Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, SC, Brazil
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