| Cognitive impairment in Parkinson's disease: tools for diagnosis and assessment. | |
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MedLine Citation:
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PMID: 19353727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cognitive impairment (CI) and dementia are frequent and debilitating features associated with Parkinson's disease (PD). Formal neuropsychological examination is required to ascertain the degree and pattern of CI over the course of the disease. The use of different tools may explain heterogeneous data obtained from studies to date. Normative data for extensively used scales [Mattis Dementia Rating Scale (MDRS), Mini-Mental State Examination (MMSE)] is incomplete in PD populations. According to sample characteristics, statistical analyses, and methodological quality, 33 studies using scales not specific to PD (MDRS, MMSE, Cambridge Cognitive Assessment, FAB) or PD-specific scales (Mini-Mental Parkinson, Scales for Outcomes of Parkinson's disease-Cognition, Parkinson's Disease-Cognitive Rating Scale, and Parkinson Neuropsychometric Dementia Assessment) were eligible for the critical analysis of their appropriateness to assess cognition in PD. Of the four scales specifically designed for PD, the SCOPA-COG and the PD-CRS have undergone extensive and rigorous validation processes. While the SCOPA-COG mainly assesses "frontal-subcortical" cognitive defects, the PD-CRS also assesses "instrumental-cortical" functions, allowing better characterization of the different patterns of CI that may be present in PD from the earliest stages. The MMP and PANDA scales were designed as brief screening tests for CI and have not yet been subjected to extensive clinimetric evaluations. Further research on PD-specific tools seems mandatory to help establish accurate cut-off scores for the diagnosis of mild PDD, detect cognitive profiles more prone to the future development of dementia, and allow comparisons between different descriptive or interventional studies. |
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Authors:
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Jaime Kulisevsky; Javier Pagonabarraga |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Movement disorders : official journal of the Movement Disorder Society Volume: 24 ISSN: 1531-8257 ISO Abbreviation: Mov. Disord. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-29 Completed Date: 2009-09-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: United States |
Other Details:
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Languages: eng Pagination: 1103-10 Citation Subset: IM |
Copyright Information:
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(c) 2009 Movement Disorder Society. |
Affiliation:
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Movement Disorders Unit, Neurology Department, Hospital de Sant Pau, Barcelona, Spain. jkulisevsky@santpau.cat |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cognition Disorders
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diagnosis*,
etiology* Humans Neuropsychological Tests* Parkinson Disease / complications* Psychiatric Status Rating Scales Psychometrics* / instrumentation, methods Questionnaires Severity of Illness Index |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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