Document Detail

Cognitive impairment in Parkinson's disease.
MedLine Citation:
PMID:  17442759     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cognitive impairment plays a role in Parkinson's disease (PD) and has important consequences for patient management. However, many aspects of cognitive impairment in PD remain unclear because of the use of different and often invalid measurement instruments. In this study, a reliable and valid instrument, the SCales for Outcomes in PArkinson's disease-COGnition (SCOPA-COG), was used.
AIM: To evaluate cognitive functioning in a large cohort of patients with Parkinson's disease and to assess the relations with demographic, disease related and clinical variables.
METHODS: A cohort of 400 patients with PD was evaluated for cognition, motor and non-motor domains, as well as for demographic and disease related characteristics. Results were compared with 150 controls matched for overall age, sex and education distribution.
RESULTS: Patients with PD scored significantly lower on all cognitive subdomains compared with controls, with the largest differences for executive functioning and memory. After correction for age and years of education, 22% of patients had impaired cognition, as measured by the total SCOPA-COG score, compared with controls. Across all patients, more severe cognitive impairment was associated with significantly more impairment in motor, autonomic, depressive and psychotic domains. Patients with the postural instability gait difficulty (PIGD) dominant phenotype showed more cognitive impairment compared with patients with the tremor dominant phenotype. Contrary to tremor scores, PIGD scores significantly worsened with increasing disease severity.
CONCLUSIONS: Cognition is an important domain of the clinical spectrum of PD and poorer cognitive performance is associated with greater impairment in motor and non-motor domains in PD. The difference in cognitive scores between PIGD dominant patients and tremor dominant patients likely reflects more advanced disease.
D Verbaan; J Marinus; M Visser; S M van Rooden; A M Stiggelbout; H A M Middelkoop; J J van Hilten
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-04-18
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  78     ISSN:  1468-330X     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-17     Completed Date:  2007-11-01     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  1182-7     Citation Subset:  IM    
Department of Neurology, K5Q-92, Leiden University Medical Centre, PO Box 9600, NL- 2300 RC Leiden, The Netherlands.
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MeSH Terms
Cognition Disorders / diagnosis*
Cohort Studies
Dementia / diagnosis
Disease Progression
Longitudinal Studies
Middle Aged
Mobility Limitation
Neurologic Examination
Neuropsychological Tests / statistics & numerical data*
Parkinson Disease / diagnosis*
Psychometrics / statistics & numerical data
Reference Values
Reproducibility of Results
Statistics as Topic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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