Document Detail


Cognitive impairment and dementia in bipolar disorder .
MedLine Citation:
PMID:  23276987     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
In bipolar disorder (BD), impaired cognition has long been described as a psychopathological feature of abnormal mood states, or accepted as treatment related side-effects. More recently, neuropsychological studies conducted in older adults have led to the recognition that enduring, irreversible cognitive changes do occur in substantial proportion of euthymic patients with life-long BD, relevant enough to warrant the diagnosis of dementia. The increased risk for dementia in BD has been associated with older age and also with factors related to the clinical course of the disease. However, it is yet to be determined whether cognitive impairment and dementia represent a complication of the most severe cases, exacerbated by biological treatments and deprivations accumulated over years, or if should be viewed as part of the natural history of BD. In the present review, we revisit the epidemiological evidence of the association between BD and dementia, and discuss the putative mechanisms supporting this association. We hypothesize that dementia may be considered as a long-term feature of BD, which is exacerbated in the presence of other risk factors.
Authors:
Orestes Vicente Forlenza; Ivan Aprahamian
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Publication Detail:
Type:  Journal Article     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Elite edition)     Volume:  5     ISSN:  1945-0508     ISO Abbreviation:  Front Biosci (Elite Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485240     Medline TA:  Front Biosci (Elite Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  258-65     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Doutor Ovidio Pires de Campos 785 - 05403-010 Sao Paulo, SP, Brazil.
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