Document Detail


Cognitive functions correlate with diffusion tensor imaging metrics in patients with spina bifida cystica.
MedLine Citation:
PMID:  21080174     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
PURPOSE: Spina bifida cystica (SBC) is a group of neurodevelopmental defects caused by improper neural tube closure, which may be responsible for deficits in cognitive functions. The purpose of this study was to examine changes in normal appearing deep gray and white matter brain regions in SBC patients compared with controls through diffusion tensor imaging (DTI) and correlate these changes with neuropsychometric tests.
METHODS: Conventional magnetic resonance imaging and neuropsychometric tests were performed on 13 patients and ten controls. DTI-derived fractional anisotropy (FA) and mean diffusivity (MD) were quantified in different brain regions in controls and patients.
RESULTS: Significantly decreased FA was observed in caudate nuclei, putamen, genu, splenium, and increased FA was found in middle cerebellar peduncle (MCP) in patients compared with controls. We observed significantly increased MD in genu and splenium. However, increased MD was found in fornix of patients compared with controls. Majority of neuropsychological tests were found to be significantly impaired and some of these showed significant correlation with DTI metrics in genu, splenium, and MCP in these patients.
CONCLUSIONS: We conclude that DTI metrics are significantly abnormal in deep gray matter nuclei, genu, splenium, and MCP in SBC patients and may provide microstructural basis for neuropsychological abnormalities in these patients.
Authors:
Manoj Kumar; Arti Srivastava; Shruti Agarwal; Sanjay Behari; Gyanendra K Malik; Ram K S Rathore; Rakesh K Gupta
Related Documents :
9189874 - Localised proton mr spectroscopy of brain metabolism changes in vegetative patients.
1486464 - Impairments of movement initiation and execution in unilateral neglect. directional hyp...
11320594 - Bedside invasive monitoring techniques in severe brain-injured patients.
10413024 - Clinical, fluorine-18 labeled 2-fluoro-2-deoxyglucose positron emission tomography of t...
19265544 - Citrate- vs. acetate-based dialysate in bicarbonate haemodialysis: consequences on haem...
3280094 - Doppler ultrasonography in the diagnosis of acute scrotal pain.
Publication Detail:
Type:  Journal Article     Date:  2010-11-16
Journal Detail:
Title:  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery     Volume:  27     ISSN:  1433-0350     ISO Abbreviation:  Childs Nerv Syst     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8503227     Medline TA:  Childs Nerv Syst     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  723-8     Citation Subset:  IM    
Affiliation:
Department of Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh, India, 226014.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Amniotic band syndrome with tethering of the spinal cord: a case-based update.
Next Document:  Learning disorders in children with epilepsy.