| Cognitive functioning in type 1 diabetes: the Diabetes Control and Complications Trial (DCCT) revisited. | |
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MedLine Citation:
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PMID: 21109995 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) study has allowed an examination of the long-term effects of type 1 diabetes and intensity of treatment on cognitive function. The association observed between chronic hyperglycaemia and mild cognitive dysfunction, affecting motor speed and psychomotor efficiency, has been re-evaluated by Jacobson et al. (Diabetologia doi: 10.1007/s00125-010-1883-9) to determine the possible contribution of macrovascular risk factors, subclinical macrovascular disease and microvascular complications (retinopathy and nephropathy). This has revealed associations between mild impairment of psychomotor efficiency and hypertension, glycaemic control and the presence of retinopathy and nephropathy, while smoking history was associated with modest abnormalities in several cognitive domains. Neither macrovascular risk factors nor a history of severe hypoglycaemia was associated with the cognitive decrements; cerebral microangiopathy has been proposed as a possible underlying cause. Although the degree of cognitive impairment was mild and limited to a few domains, these decrements may influence the performance of everyday activities, such as driving. |
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Authors:
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B M Frier |
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Publication Detail:
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Type: Comment; Journal Article Date: 2010-11-26 |
Journal Detail:
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Title: Diabetologia Volume: 54 ISSN: 1432-0428 ISO Abbreviation: Diabetologia Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0006777 Medline TA: Diabetologia Country: Germany |
Other Details:
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Languages: eng Pagination: 233-6 Citation Subset: IM |
Affiliation:
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Department of Diabetes, Royal Infirmary, Edinburgh, Scotland, EH16 4SA, UK. brian.frier@luht.scot.nhs.uk |
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| Comments/Corrections | |
Comment On:
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Diabetologia. 2011 Feb;54(2):245-55
[PMID:
20803190
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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