Document Detail


Cognitive function of patients with brain tumor in pre- and postoperative stage.
MedLine Citation:
PMID:  18054616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Nobody knows whether cognitive dysfunction affects survival. Furthermore, it is unknown whether the dysfunction is caused by the tumor itself or by its treatment. METHODS: Patients with 20 gliomas (LGG, 7; MG, 13 [AG, 4; GM, 9]) in the right brain (nondominant) and 11 gliomas (LGG, 1; MG, 10 [AG, 6; GM, 4]) in the left brain (dominant) were studied. Thirty-four patients with meningioma were also studied. Cognitive function was evaluated by the 3MS examination, and propriety of radical resection of tumor was reviewed. RESULTS: Cognitive function pre-Op and post-Op was normal in patients with LGG and MGs in the right brain but decreased before an Op in all patients with MG in the left brain, and they did not normalize after Op. In patients with MG in left brain, the test of temporal and spatial orientation, first recall, similarities, 4-legged animals, mental reversal, and writing decreased after Op. Cognitive hypofunction before or after Op did not correlate with tumor malignancy and degree of tumor resection. CONCLUSION: Firstly, radical Op should aim at improvement of cognitive function for patients with glioma in the right brain, and for patients with glioma in the left brain, QOL should be thought about without expecting improvement of cognitive function. Secondly, improvement of cognitive function cannot be anticipated in patients with meningioma in the left brain. Aged patients older than 75 years require carefulness in Op. Then, damage of the cingulated gyrus and corpus callosum should be avoided in the left brain. This study emphasizes that clinicians should be careful in the evaluation of cognitive function in glioma and meningioma treatment.
Authors:
Yoshihiko Yoshii; Daisuke Tominaga; Kouichi Sugimoto; Yukihiro Tsuchida; Akio Hyodo; Hirokatsu Yonaha; Sukemitsu Kushi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgical neurology     Volume:  69     ISSN:  0090-3019     ISO Abbreviation:  Surg Neurol     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0367070     Medline TA:  Surg Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  51-61; discussion 61     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Faculty of Clinical Medicine, University of the Ryukyus, Nishihara-cho, Okinawa-903, Japan. yoshihiko@med.u-ryukyu.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Brain Neoplasms / pathology,  psychology*,  surgery
Cognition / physiology*
Female
Follow-Up Studies
Glioma / pathology,  psychology*,  surgery
Humans
Male
Meningeal Neoplasms / pathology,  psychology*,  surgery
Meningioma / pathology,  psychology*,  surgery
Middle Aged
Neuropsychological Tests
Prospective Studies
Recovery of Function / physiology
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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