Document Detail

Cognitive function and neurophysiological evaluation in early-treated hypothyroid children.
MedLine Citation:
PMID:  11286043     Owner:  NLM     Status:  MEDLINE    
In this study, we assessed cognitive function and neurophysiological development in congenitally hypothyroid (CH) children. We performed a cross-sectional study at the outpatient Pediatric Clinic and Department of Neurophysiology at San Raffaele Hospital, Milan. The study enrolled 25 CH patients (6.00-10.83 years of age) detected by neonatal screening, and 34 healthy control children (4-11 years of age). Patients and controls had comparable scores at neuropsychological tests (WISC-R), and at auditory P300 tests. In contrast, we found significantly longer LLSEP latencies in CH patients (p < 0.03). CH patients treated 30 days after birth showed lower scores at neuropsychological tests, but not at neurophysiological tests, compared to patients who started the replacement therapy earlier. Patients with more severe fetal hypothyroidism (T4 levels at diagnosis < or = 2 micrograms/dl) had lower neuropsychological scores, and similar neurophysiological results, compared with patients with moderate fetal hypothyroidism. The severity of fetal hypothyroidism and early treatment influence the mental outcome of CH patients. Neurophysiological results show that central nervous system damage occurs in some patients despite early treatment.
G Weber; S Mora; L M Prina Cerai; V Siragusa; J Colombini; S Medaglini; C Fornara; T Locatelli; G Comi; G Chiumello
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology     Volume:  21     ISSN:  1590-1874     ISO Abbreviation:  Neurol. Sci.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-04-04     Completed Date:  2001-07-12     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  100959175     Medline TA:  Neurol Sci     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  307-14     Citation Subset:  IM    
Department of Pediatrics Endocrine Unit, Scientific Institute H San Raffaele, University of Milan, Via Olgettina 60, I-20132 Milan, Italy.
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MeSH Terms
Child, Preschool
Cognition / physiology*
Congenital Hypothyroidism
Event-Related Potentials, P300 / physiology
Evoked Potentials, Auditory / physiology
Evoked Potentials, Somatosensory / physiology
Hormone Replacement Therapy
Hypothyroidism / drug therapy,  psychology*
Intelligence Tests
Neural Pathways / physiology
Neuropsychological Tests*
Psychomotor Performance / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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