Document Detail

Cognitive function in primary progressive and transitional progressive multiple sclerosis: a controlled study with MRI correlates.
MedLine Citation:
PMID:  10388799     Owner:  NLM     Status:  MEDLINE    
The relative rarity of primary progressive (PP) and transitional progressive (TP) multiple sclerosis has meant that little documentation of cognitive function in such patients is currently available. The aim of this study was to investigate the cognitive skills of patients with PP and TP multiple sclerosis relative to matched healthy controls, and to examine the relationship of this impairment to MRI parameters. Sixty-three patients (43 PP, 20 TP) were individually matched with healthy controls, who undertook the same cognitive tasks as the patient group. The neuropsychological assessment comprised Rao's brief repeatable battery, a reasoning test, and a measure of depression. Patients also underwent T1- and T2-weighted brain MRI. These patients were taken from a larger cohort (158 PP, 33 TP) in whom it had been demonstrated that the re were no significant differences between the mean scores of the PP and TP groups on any of the cognitive variables. The 63 patients were therefore taken as one group for comparison with the healthy controls. These patients performed significantly worse than the controls in tests of verbal memory, attention, verbal fluency and spatial reasoning. An impairment index was constructed and applied to the patient data. This correlated modestly with T2-lesion load (r = 0.45, P = 0.01), T1-hypointensity load (r = 0.45, P = 0.01) and cerebral volume (r = -0.35, P = 0.01). Thus, PP and TP multiple sclerosis patients demonstrate significant cognitive dysfunction when compared with matched healthy controls. The relationship between this impairment and MRI parameters is moderate, suggesting that cognitive dysfunction in PP and TP multiple sclerosis has a complex and multifactorial aetiology, which is not adequately explained by pathology as demonstrated on conventional MRI.
S J Camp; V L Stevenson; A J Thompson; D H Miller; C Borras; S Auriacombe; B Brochet; M Falautano; M Filippi; L Hérissé-Dulo; X Montalban; E Parrcira; C H Polman; J De Sa; D W Langdon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain : a journal of neurology     Volume:  122 ( Pt 7)     ISSN:  0006-8950     ISO Abbreviation:  Brain     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-08-10     Completed Date:  1999-08-10     Revised Date:  2011-11-03    
Medline Journal Info:
Nlm Unique ID:  0372537     Medline TA:  Brain     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1341-8     Citation Subset:  AIM; IM    
Department of Clinical Neurology, Institute of Neurology, London, UK.
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MeSH Terms
Cognition / physiology*
Magnetic Resonance Imaging
Middle Aged
Multiple Sclerosis / diagnosis,  physiopathology*,  psychology*
Neuropsychological Tests
Reference Values
Grant Support
491//Multiple Sclerosis Society

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