Document Detail

Cognitive function in patients with cerebral arteriovenous malformations after radiosurgery: prospective long-term follow-up.
MedLine Citation:
PMID:  12459366     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the long-term cognitive function of patients with cerebral arteriovenous malformations (AVMs) after radiosurgery. METHODS AND MATERIALS: The data of 95 AVM patients were prospectively assessed up to 3 years after radiosurgery. Of these patients, 39 had a follow-up of at least 2 years. Radiosurgery was performed using a modified linear accelerator (minimal doses to the target volume 15-22 Gy, median dose 20). The neuropsychological evaluation included testing of intelligence, attention, and memory. The effect of a preexisting intracranial hemorrhage, as well as AVM occlusion, on cognitive functions was analyzed after 1 and 2 years. RESULTS: No cognitive declines were observed during follow-up. Instead significant improvements occurred in intelligence (1 year, +6.1 IQ points; 2 years, +5.1 IQ points), memory (1 year, +18.3 percentile score; 2 years, +12.2 percentile score), and attention (1 year, +19 percentile score; 2 years, +18 percentile score). Patients without previous intracranial hemorrhage improved more than patients with intracranial hemorrhage, although this difference was not statistically significant. The role of AVM occlusion on cognitive function is not clear at present. CONCLUSION: Radiosurgery does not induce measurable deterioration of cognitive function in patients with cerebral AVMs.
Sarah Steinvorth; Frederik Wenz; Susanne Wildermuth; Marco Essig; Martin Fuss; Frank Lohr; Jürgen Debus; Michael Wannenmacher; Werner Hacke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of radiation oncology, biology, physics     Volume:  54     ISSN:  0360-3016     ISO Abbreviation:  Int. J. Radiat. Oncol. Biol. Phys.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-02     Completed Date:  2003-01-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7603616     Medline TA:  Int J Radiat Oncol Biol Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1430-7     Citation Subset:  IM    
Department of Neurology, University of Heidelberg, Heidelberg, Germany.
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MeSH Terms
Cognition / radiation effects*
Follow-Up Studies
Intracranial Arteriovenous Malformations / etiology*
Middle Aged
Neuropsychological Tests
Particle Accelerators
Radiosurgery / adverse effects*
Time Factors

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