Document Detail

Cognitive function in adult adrenoleukodystrophy: comparison with leukoaraiosis and multiple sclerosis.
MedLine Citation:
PMID:  1817029     Owner:  NLM     Status:  MEDLINE    
Cognitive evaluation of 6 cases of adult adrenoleukodystrophy (ALD) included in a brain magnetic resonance (MR) study are reported: 2 males with adrenomyeloneuropathy and 4 women heterozygous for ALD. Cognition was normal in 4 and MR scan in 2 of them. In the 2 others, there were mild modifications of the white matter. One patient suffered of visual retention disturbances with abnormalities of the white matter in MR scan. In the last, cognitive decline was observed; MR scan showed atrophy of cortex and corpus callosum and periventricular high signal areas. Comparison with leukoaraiosis in healthy adults and with multiple sclerosis suggests that there is probably a relationship between cognition and extension of brain MR abnormalities. Time of appearance and frequency of cognitive dysfunction might be explained by the natural history of each of these diseases.
O Lyon-Caen; N Benoit; V Carreau; M Montreuil; P Menage; C Lubetzki; E Cabanis; M T Iba-Zizen; A Tourbah; N Baumann
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental neuroscience     Volume:  13     ISSN:  0378-5866     ISO Abbreviation:  Dev. Neurosci.     Publication Date:  1991  
Date Detail:
Created Date:  1992-07-09     Completed Date:  1992-07-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7809375     Medline TA:  Dev Neurosci     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  251-3     Citation Subset:  IM    
Service de Neurologie et de Neuropsychologie, Hôpital de la Salpêtrière, Paris, France.
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MeSH Terms
Adrenoleukodystrophy / complications,  pathology,  psychology*
Brain / pathology*
Cognition Disorders / etiology,  pathology,  psychology
Magnetic Resonance Imaging
Middle Aged
Multiple Sclerosis / complications,  pathology,  psychology*
Nerve Fibers, Myelinated / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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