| Cognitive function effects of suppressing ovarian hormones in young women. | |
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MedLine Citation:
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PMID: 12082358 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the effect of a pharmacologically induced, temporary suppression of ovarian hormones on healthy young women's cognitive functioning. DESIGN: Sixteen healthy women with normal menstrual cycles completed the California Verbal Learning Test, a digit span test, and a verbal fluency test in the follicular phase of a normal menstrual cycle and a second time after four monthly injections of the gonadotropin-releasing hormone (GnRH) agonist. Women were randomly assigned to complete a third testing either after resuming cycles in the follicular phase or after three more injections of the GnRH agonist and while wearing an estradiol patch. The control group consisted of 10 women who were tested three times in the follicular phase of their menstrual cycles. RESULTS: Results showed no change in cognitive functioning across sessions or groups in women with suppressed ovarian function. Women who had the highest levels of menopausal symptoms when taking the GnRH agonist did not have significantly lower cognitive functioning. CONCLUSIONS: This study did not find any effect of suppression in ovarian hormones on cognitive performance of young women. |
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Authors:
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Jane F Owens; Karen A Matthews; Susan A Everson |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Menopause (New York, N.Y.) Volume: 9 ISSN: 1072-3714 ISO Abbreviation: Menopause Publication Date: 2002 Jul-Aug |
Date Detail:
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Created Date: 2002-06-25 Completed Date: 2002-09-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9433353 Medline TA: Menopause Country: United States |
Other Details:
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Languages: eng Pagination: 227-35 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA. owensjf@msx.upmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Cognition / drug effects* Delayed-Action Preparations / administration & dosage* Estradiol / administration & dosage* Female Follicle Stimulating Hormone / blood Gonadotropin-Releasing Hormone / antagonists & inhibitors* Humans Intelligence Tests Luteinizing Hormone / blood Menstrual Cycle / drug effects*, physiology Probability Reference Values Sensitivity and Specificity |
| Grant Support | |
ID/Acronym/Agency:
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HL07011/HL/NHLBI NIH HHS; HL38712/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Delayed-Action Preparations; 33515-09-2/Gonadotropin-Releasing Hormone; 50-28-2/Estradiol; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone |
| Comments/Corrections | |
Comment In:
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Menopause. 2002 Jul-Aug;9(4):221-3
[PMID:
12082356
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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