Document Detail

Cognitive factors in schizophrenia: causes, impact, and treatment.
MedLine Citation:
PMID:  15475873     Owner:  NLM     Status:  MEDLINE    
Greater attention has been given to the cognitive dimension in schizophrenia in recent years. This has resulted from increased recognition that cognitive impairment and negative symptoms of the disease have a greater impact on quality of life (QOL) compared to positive symptoms. Successful treatment of positive symptoms in patients with schizophrenia has not been shown to robustly translate into improvements in employment status or social relationships, while cognitive improvements are strongly associated with these important aspects of QOL and independence. These findings are based on extensive testing with standard cognitive tests for measuring executive function, verbal learning and memory, word recall, verbal working memory, spatial working memory, attention, and vigilance. Verbal learning and executive function, in particular, have been found to be valid predictors of employment success independent of the degree of severity of positive symptoms.
Herbert Y Meltzer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  CNS spectrums     Volume:  9     ISSN:  1092-8529     ISO Abbreviation:  CNS Spectr     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-11     Completed Date:  2005-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9702877     Medline TA:  CNS Spectr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15-24     Citation Subset:  IM    
Division of Psychopharmacology, Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212-8645, USA.
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MeSH Terms
Antipsychotic Agents / therapeutic use*
Brain / drug effects
Cognition Disorders / diagnosis,  etiology*,  prevention & control*
Neuropsychological Tests
Quality of Life
Schizophrenia / complications*,  drug therapy*
Severity of Illness Index
Reg. No./Substance:
0/Antipsychotic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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