| Cognitive factors in schizophrenia: causes, impact, and treatment. | |
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MedLine Citation:
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PMID: 15475873 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Greater attention has been given to the cognitive dimension in schizophrenia in recent years. This has resulted from increased recognition that cognitive impairment and negative symptoms of the disease have a greater impact on quality of life (QOL) compared to positive symptoms. Successful treatment of positive symptoms in patients with schizophrenia has not been shown to robustly translate into improvements in employment status or social relationships, while cognitive improvements are strongly associated with these important aspects of QOL and independence. These findings are based on extensive testing with standard cognitive tests for measuring executive function, verbal learning and memory, word recall, verbal working memory, spatial working memory, attention, and vigilance. Verbal learning and executive function, in particular, have been found to be valid predictors of employment success independent of the degree of severity of positive symptoms. |
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Authors:
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Herbert Y Meltzer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: CNS spectrums Volume: 9 ISSN: 1092-8529 ISO Abbreviation: CNS Spectr Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-10-11 Completed Date: 2005-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9702877 Medline TA: CNS Spectr Country: United States |
Other Details:
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Languages: eng Pagination: 15-24 Citation Subset: IM |
Affiliation:
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Division of Psychopharmacology, Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212-8645, USA. herbert.meltzer@vanderbilt.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antipsychotic Agents
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therapeutic use* Brain / drug effects Cognition Disorders / diagnosis, etiology*, prevention & control* Humans Neuropsychological Tests Quality of Life Schizophrenia / complications*, drug therapy* Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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