Document Detail

Cognitive effects of two nutraceuticals Ginseng and Bacopa benchmarked against modafinil: a review and comparison of effect sizes.
MedLine Citation:
PMID:  23043278     Owner:  NLM     Status:  MEDLINE    
Over recent years there has been increasing research into both pharmaceutical and nutraceutical cognition enhancers. Here we aimed to calculate the effect sizes of positive cognitive effect of the pharmaceutical modafinil in order to benchmark the effect of two widely used nutraceuticals Ginseng and Bacopa (which have consistent acute and chronic cognitive effects, respectively). A search strategy was implemented to capture clinical studies into the neurocognitive effects of modafinil, Ginseng and Bacopa. Studies undertaken on healthy human subjects using a double-blind, placebo-controlled design were included. For each study where appropriate data were included, effect sizes (Cohen's d) were calculated for measures showing significant positive and negative effects of treatment over placebo. The highest effect sizes for cognitive outcomes were 0.77 for modafinil (visuospatial memory accuracy), 0.86 for Ginseng (simple reaction time) and 0.95 for Bacopa (delayed word recall). These data confirm that neurocognitive enhancement from well characterized nutraceuticals can produce cognition enhancing effects of similar magnitude to those from pharmaceutical interventions. Future research should compare these effects directly in clinical trials.
Chris Neale; David Camfield; Jonathon Reay; Con Stough; Andrew Scholey
Related Documents :
9403688 - Fear conditioning induces associative long-term potentiation in the amygdala.
15049508 - Molecular signals into the insular cortex and amygdala during aversive gustatory memory...
8189188 - Topography of sexually conditioned behavior in male japanese quail (coturnix japonica) ...
863118 - Early learning and retention of a conditioned taste aversion.
24898118 - The roles of associative and executive processes in creative cognition.
15762378 - Simultaneous visual discrimination in asian elephants.
Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  75     ISSN:  1365-2125     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-06     Completed Date:  2013-08-06     Revised Date:  2014-03-09    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  728-37     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Benzhydryl Compounds / therapeutic use*
Central Nervous System Stimulants / therapeutic use*
Clinical Trials as Topic
Cognition / drug effects*
Dietary Supplements*
Dose-Response Relationship, Drug
Memory / drug effects
Nootropic Agents / pharmacology*
Psychomotor Performance / drug effects
Reg. No./Substance:
0/Benzhydryl Compounds; 0/Central Nervous System Stimulants; 0/Nootropic Agents; R3UK8X3U3D/modafinil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Expression profiling of genes involved in the formation of aroma in two peach genotypes.
Next Document:  HINT1 mutations define a novel disease entity - Autosomal Recessive Axonal Neuropathy with Neuromyot...