| Cognitive effects of endocrine-disrupting chemicals in animals. | |
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MedLine Citation:
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PMID: 11748026 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A large number of chemical pollutants including phthalates, alkylphenolic compounds, polychlorinated biphenyls and polychlorinated dibenzodioxins, organochlorine pesticides, bisphenol A, and metals including lead, mercury, and cadmium have the ability to disrupt endocrine function in animals. Some of these same chemicals have been shown to alter cognitive function in animals and humans. Because hormonally mediated events play a central role in central nervous system development and function, a number of researchers have speculated that the changes in cognitive function are mediated by the endocrine-like actions of these chemicals. In this paper we review the evidence that cognitive effects of chemicals classified as environmental endocrine disruptors are mediated by changes in hormonal function. We begin by briefly reviewing the role of gonadal steroids, thyroid hormones, and glucocorticoids in brain development and brain function. We then review the endocrine changes and cognitive effects that have been reported for selected endocrine-disrupting chemicals, discuss the evidence for causal relationships between endocrine disruption and cognitive effects, and suggest directions for future research. |
Authors:
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S L Schantz; J J Widholm |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Environmental health perspectives Volume: 109 ISSN: 0091-6765 ISO Abbreviation: Environ. Health Perspect. Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2001-12-18 Completed Date: 2002-02-05 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0330411 Medline TA: Environ Health Perspect Country: United States |
Other Details:
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Languages: eng Pagination: 1197-206 Citation Subset: IM |
Affiliation:
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Department of Veterinary Biosciences and Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA. schantz@uiuc.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal Brain / drug effects, growth & development* Cognition / drug effects* Endocrine System / drug effects* Female Glucocorticoids / pharmacology Gonadal Steroid Hormones / pharmacology Learning / drug effects* Male Memory / drug effects* Rats Thyroid Hormones / pharmacology Xenobiotics / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Gonadal Steroid Hormones; 0/Thyroid Hormones; 0/Xenobiotics |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): Environ Health Perspect ISSN: 0091-6765 |
Article Information Download PDF  Print publication date: Month: 12 Year: 2001 Volume: 109 Issue: 12 First Page: 1197 Last Page: 1206 ID: 1240501 PubMed Id: 11748026 Publisher Item Identifier: sc271_5_1835 |
| Cognitive effects of endocrine-disrupting chemicals in animals. | |
| S L Schantz | |
| J J Widholm | |
| Department of Veterinary Biosciences and Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA. schantz@uiuc.edu |
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