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Cognitive effects of endocrine-disrupting chemicals in animals.
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MedLine Citation:
PMID:  11748026     Owner:  NLM     Status:  MEDLINE    
A large number of chemical pollutants including phthalates, alkylphenolic compounds, polychlorinated biphenyls and polychlorinated dibenzodioxins, organochlorine pesticides, bisphenol A, and metals including lead, mercury, and cadmium have the ability to disrupt endocrine function in animals. Some of these same chemicals have been shown to alter cognitive function in animals and humans. Because hormonally mediated events play a central role in central nervous system development and function, a number of researchers have speculated that the changes in cognitive function are mediated by the endocrine-like actions of these chemicals. In this paper we review the evidence that cognitive effects of chemicals classified as environmental endocrine disruptors are mediated by changes in hormonal function. We begin by briefly reviewing the role of gonadal steroids, thyroid hormones, and glucocorticoids in brain development and brain function. We then review the endocrine changes and cognitive effects that have been reported for selected endocrine-disrupting chemicals, discuss the evidence for causal relationships between endocrine disruption and cognitive effects, and suggest directions for future research.
S L Schantz; J J Widholm
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Environmental health perspectives     Volume:  109     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-18     Completed Date:  2002-02-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1197-206     Citation Subset:  IM    
Department of Veterinary Biosciences and Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA.
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MeSH Terms
Behavior, Animal
Brain / drug effects,  growth & development*
Cognition / drug effects*
Endocrine System / drug effects*
Glucocorticoids / pharmacology
Gonadal Steroid Hormones / pharmacology
Learning / drug effects*
Memory / drug effects*
Thyroid Hormones / pharmacology
Xenobiotics / adverse effects*
Reg. No./Substance:
0/Glucocorticoids; 0/Gonadal Steroid Hormones; 0/Thyroid Hormones; 0/Xenobiotics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 12 Year: 2001
Volume: 109 Issue: 12
First Page: 1197 Last Page: 1206
ID: 1240501
PubMed Id: 11748026
Publisher Item Identifier: sc271_5_1835

Cognitive effects of endocrine-disrupting chemicals in animals.
S L Schantz
J J Widholm
Department of Veterinary Biosciences and Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA.

Article Categories:
  • Research Article

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