Document Detail

Cognitive development in children with Dravet syndrome.
MedLine Citation:
PMID:  21463278     Owner:  NLM     Status:  In-Process    
Slowing of cognitive skills represents one of the diagnostic criteria of Dravet syndrome. This Italian multicentric study aims at clarifying the roles of epilepsy and/or underlying genetic alteration in determining the cognitive outcome. The study includes infants that were either in follow-up (retrospective study: 26 cases) and newly diagnosed (prospective study: in progress). Our multicentric study shows that slowing of cognitive achievements becomes evident during the second year of life in all cases, and that the epilepsy phenotype indeed has a prognostic value. In this study the early appearance of absences and myoclonic seizures is associated with the worst cognitive outcome; whereas convulsive prolonged seizures do not seem to represent, per se, a bad prognostic factor for mental outcome. In this study, statistical analysis failed to reveal differences in the cognitive outcome with regard to the presence and type of SCN1A mutation.
Francesca Ragona
Related Documents :
25431618 - How the object of affect guides its impact.
20646058 - Ampa receptor trafficking and learning.
19594278 - Learned predictiveness effects in humans: a function of learning, performance, or both?
3936108 - Selective impairment of paired associate learning after administration of a centrally-a...
12954418 - Changes in cholinergic enzyme activities in the cuttlefish brain during memory formation.
21859928 - Negative transfer in human associative learning.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Epilepsia     Volume:  52 Suppl 2     ISSN:  1528-1167     ISO Abbreviation:  Epilepsia     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39-43     Citation Subset:  IM    
Copyright Information:
Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.
Department of Pediatric Neuroscience, IRCCS Foundation Neurological Institute C Besta, Milano, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cognitive and behavioral characteristics of children with Dravet syndrome: an overview.
Next Document:  Dravet syndrome: the long-term outcome.