Document Detail

Cognitive deterioration due to GH deficiency in patients with traumatic brain injury: a preliminary report.
MedLine Citation:
PMID:  17676444     Owner:  NLM     Status:  MEDLINE    
PRIMARY OBJECTIVE: To determine whether cognitive and behavioural disorders observed in TBI patients are due to hormonal deficits or to the brain injury itself.
RESEARCH DESIGN: Transversal, between-group design.
METHODS AND PROCEDURES: Studied 22 severe TBI patients (GCS < 8): 11 had isolated GH deficiency and 11 did not. Prepared detailed clinical reports on patients and performed physical examinations, standard biochemical and full blood count analysis. Patients underwent neuropsychological assessment and hormonal evaluation 6 months after TBI diagnosis.
RESULTS: TBI patients with GH deficiency show greater deficits in attention, executive functioning, memory and emotion than those without GH deficiency.
CONCLUSIONS: Results show GH-related cognitive impairment in patients who develop GH deficiency after TBI and suggest that treatment of GH deficiency would improve cognition. The clinical importance of these findings should be established to better understand the nature, magnitude and meaning of GH-related cognitive impairment in patients who develop GH deficiency after TBI.
J León-Carrión; A Leal-Cerro; F Murillo Cabezas; A Madrazo Atutxa; S García Gomez; J M Flores Cordero; A Soto Moreno; M D Rincón Ferrari; M R Domínguez-Morales
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain injury     Volume:  21     ISSN:  0269-9052     ISO Abbreviation:  Brain Inj     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-08-06     Completed Date:  2008-02-05     Revised Date:  2014-11-14    
Medline Journal Info:
Nlm Unique ID:  8710358     Medline TA:  Brain Inj     Country:  England    
Other Details:
Languages:  eng     Pagination:  871-5     Citation Subset:  IM    
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MeSH Terms
Brain Injuries / blood*,  psychology*
Case-Control Studies
Cognition Disorders / blood*,  etiology*
Follow-Up Studies
Glasgow Coma Scale
Human Growth Hormone / blood*,  deficiency*
Neuropsychological Tests
Time Factors
Reg. No./Substance:
12629-01-5/Human Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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