| Cognitive deterioration associated with focal cortical dysplasia. | |
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MedLine Citation:
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PMID: 10029267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Surgery for an area of focal cortical dysplasia in a critical region is reported in a right-handed female manifesting intractable focal epilepsy and verbal cognitive deterioration. She developed the first seizure at 2 years of age and was treated with phenytoin and zonisamide, with good control until 10 years of age. Although seizures did not occur at 9 years of age, she manifested dyscalculia, right-left disorientation, and finger agnosia, and N-isopropyl-p-iodoamphetamine single-photon emission computed tomography (SPECT) revealed focal hypoperfusion in the left parietal lobe. At 11 years of age, she developed regular nocturnal seizures and gradually lost the ability to understand the meaning of sentences. Verbal IQ declined from 94 to 63, and the area of hypoperfusion detected by interictal N-isopropyl-p-iodoamphetamine SPECT spread over the left parietotemporal lobes. Magnetic resonance imaging revealed focal cortical dysplasia mainly in the left parietal lobe, and ictal technetium-99m-ethyl cysteinate dimer SPECT images demonstrated an area of hyperperfusion around the focal cortical dysplasia, including the left precentral gyrus. Because of the overlap between the epileptogenic and functional cortex, the authors concluded that cortical resection, including focal cortical dysplasia, was inappropriate in this patient. |
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Authors:
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J Oki; A Miyamoto; S Takahashi; H Takei |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric neurology Volume: 20 ISSN: 0887-8994 ISO Abbreviation: Pediatr. Neurol. Publication Date: 1999 Jan |
Date Detail:
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Created Date: 1999-05-05 Completed Date: 1999-05-05 Revised Date: 2006-05-23 |
Medline Journal Info:
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Nlm Unique ID: 8508183 Medline TA: Pediatr Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 73-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Asahikawa Medical College, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cerebral Cortex
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abnormalities*,
pathology Child Cognition Disorders / etiology* Developmental Disabilities / etiology Disease Progression Electroencephalography Epilepsies, Partial / drug therapy, etiology*, physiopathology Female Humans Magnetic Resonance Imaging Parietal Lobe / abnormalities Tomography, Emission-Computed, Single-Photon |
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