| Cognitive deficits and associated neurological complications in individuals with Down's syndrome. | |
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MedLine Citation:
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PMID: 20494326 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Improvements in medical interventions for people with Down's syndrome have led to a substantial increase in their longevity. Diagnosis and treatment of neurological complications are important in maintaining optimal cognitive functioning. The cognitive phenotype in Down's syndrome is characterised by impairments in morphosyntax, verbal short-term memory, and explicit long-term memory. However, visuospatial short-term memory, associative learning, and implicit long-term memory functions are preserved. Seizures are associated with cognitive decline and seem to cause additional decline in cognitive functioning, particularly in people with Down's syndrome and comorbid disorders such as autism. Vision and hearing disorders as well as hypothyroidism can negatively impact cognitive functioning in people with Down's syndrome. Dementia that resembles Alzheimer's disease is common in adults with Down's syndrome. Early-onset dementia in adults with Down's syndrome does not seem to be associated with atherosclerotic complications. |
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Authors:
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Ira T Lott; Mara Dierssen |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Lancet neurology Volume: 9 ISSN: 1474-4465 ISO Abbreviation: Lancet Neurol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-24 Completed Date: 2010-06-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101139309 Medline TA: Lancet Neurol Country: England |
Other Details:
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Languages: eng Pagination: 623-33 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Pediatrics, University of California Irvine School of Medicine, Orange, CA 92868, USA. itlott@uci.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Diseases / epidemiology, pathology, physiopathology* Cognition Disorders / epidemiology, pathology, physiopathology* Comorbidity Down Syndrome / epidemiology, pathology, physiopathology* Humans |
| Grant Support | |
ID/Acronym/Agency:
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AG 16573/AG/NIA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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