Document Detail

Cognitive decline in older adults with a history of traumatic brain injury.
MedLine Citation:
PMID:  23153408     Owner:  NLM     Status:  MEDLINE    
Traumatic brain injury (TBI) is an important public health problem with potentially serious long-term neurobehavioural sequelae. There is evidence to suggest that a history of TBI can increase a person's risk of developing Alzheimer's disease. However, individuals with dementia do not usually have a history of TBI, and survivors of TBI do not invariably acquire dementia later in life. Instead, a history of traumatic brain injury, combined with brain changes associated with normal ageing, might lead to exacerbated cognitive decline in older adults. Strategies to increase or maintain cognitive reserve might help to prevent exacerbated decline after TBI. Systematic clinical assessment could help to differentiate between exacerbated cognitive decline and mild cognitive impairment, a precursor of Alzheimer's disease, with important implications for patients and their families.
Laura Moretti; Irene Cristofori; Starla M Weaver; Aileen Chau; Jaclyn N Portelli; Jordan Grafman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Lancet. Neurology     Volume:  11     ISSN:  1474-4465     ISO Abbreviation:  Lancet Neurol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-16     Completed Date:  2013-01-18     Revised Date:  2014-08-15    
Medline Journal Info:
Nlm Unique ID:  101139309     Medline TA:  Lancet Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1103-12     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Aging / psychology*
Brain / pathology
Brain Injuries / diagnosis,  epidemiology*,  psychology*
Cognition Disorders / diagnosis,  epidemiology*,  psychology*
Diagnosis, Differential
Comment In:
Lancet Neurol. 2012 Dec;11(12):1020-1   [PMID:  23153401 ]

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