Document Detail

Cognitive decline in incident Alzheimer disease in a community population.
MedLine Citation:
PMID:  20308679     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To measure the cognitive consequences of incident Alzheimer disease (AD) in older African American and white subjects.
METHODS: Data are from the Chicago Health and Aging Project, a longitudinal cohort study of older white and black persons residing in a geographically defined community. At 3-year intervals, the entire study population completed 4 brief cognitive tests, from which a previously established composite measure of global cognition was derived, and a subset underwent detailed clinical evaluation that supported clinical classification of mild cognitive impairment, dementia, and AD. We used mixed-effects models to examine change in cognitive function following the diagnostic evaluation.
RESULTS: On clinical evaluation, 614 persons were found to have no cognitive impairment, 395 had mild cognitive impairment, and 149 had AD (88.5% mild); 10 persons with other dementias were excluded from analyses. During up to 11 years of observation following the clinical evaluation (mean = 5.5, SD = 2.5), the composite measure of global cognition declined a mean of 0.042 unit per year (SE = 0.008, p < 0.001) in those with no cognitive impairment. In comparison to the no cognitive impairment group, the annual rate of decline was increased more than twofold in mild cognitive impairment (estimate = 0.086, SE = 0.011, p < 0.001) and more than fourfold in AD (estimate = 0.173, SE = 0.020, p < 0.001). Results did not reliably vary by race, sex, or age.
CONCLUSIONS: Alzheimer disease has a devastating impact on cognition, even in its prodromal stages, with comparable effects in African American and white persons.
R S Wilson; N T Aggarwal; L L Barnes; C F Mendes de Leon; L E Hebert; D A Evans
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Neurology     Volume:  74     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-23     Completed Date:  2010-04-06     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  951-5     Citation Subset:  AIM; IM    
Rush AD Center, Rush University Medical Center, 600 South Paulina Avenue, Suite 1038, Chicago, IL 60612, USA.
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MeSH Terms
African Continental Ancestry Group / statistics & numerical data
Alzheimer Disease / epidemiology*
Cognition Disorders / diagnosis,  epidemiology*
Cohort Studies
Decision Support Techniques
Disease Progression
European Continental Ancestry Group / statistics & numerical data
Longitudinal Studies
Grant Support
Comment In:
Neurology. 2010 Aug 17;75(7):669-70   [PMID:  20713957 ]
Neurology. 2010 Mar 23;74(12):942-4   [PMID:  20308677 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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