Document Detail

Cognitive changes after menopause: influence of estrogen.
MedLine Citation:
PMID:  18677155     Owner:  NLM     Status:  MEDLINE    
The natural menopause is not associated with substantial cognitive change. Limited clinical trial evidence suggests that estrogen-containing hormone therapy has little effect on cognition during midlife, but prompt initiation after surgical menopause may improve aspects of memory. Among older postmenopausal women, strong clinical trial evidence demonstrates that hormone initiation does not improve cognition. More limited clinical trial evidence indicates no improvement in Alzheimer symptoms, and the Women's Health Initiative Memory Study found an increase in dementia risk among older women. Observational findings of reduced Alzheimer risk may reflect early hormone use in younger women, or findings may be biased. Cognitive effects of selective estrogen receptor modulators are not yet well studied.
Victor W Henderson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Clinical obstetrics and gynecology     Volume:  51     ISSN:  1532-5520     ISO Abbreviation:  Clin Obstet Gynecol     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-04     Completed Date:  2008-10-23     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0070014     Medline TA:  Clin Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  618-26     Citation Subset:  IM    
Departmentsof Health Research and Policy (Epidemiology), Stanford University, Stanford, California 94305-5405, USA.
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MeSH Terms
Alzheimer Disease / chemically induced,  epidemiology
Cognition / drug effects*
Cognition Disorders / chemically induced*,  epidemiology
Dementia / chemically induced,  epidemiology
Estrogen Replacement Therapy / adverse effects,  methods*
Estrogens / adverse effects,  therapeutic use
Menopause / psychology*
Progestins / adverse effects,  therapeutic use
Grant Support
R01 AG023038/AG/NIA NIH HHS; R01 AG023038-03/AG/NIA NIH HHS
Reg. No./Substance:
0/Estrogens; 0/Progestins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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