Document Detail

Cognitive and cardiac outcomes 5 years after off-pump vs on-pump coronary artery bypass graft surgery.
MedLine Citation:
PMID:  17312289     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Conventional coronary artery bypass graft surgery with use of cardiopulmonary bypass (on-pump CABG) is associated with excellent long-term cardiac outcomes but also with a high incidence of cognitive decline. The effect of avoiding cardiopulmonary bypass (off-pump CABG) on long-term cognitive and cardiac outcomes is unknown.
OBJECTIVE: To compare the effect of off-pump CABG and on-pump CABG surgery on long-term cognitive and cardiac outcomes.
DESIGN, SETTING, AND PARTICIPANTS: The Octopus Study, a multicenter randomized controlled trial conducted in the Netherlands, which enrolled 281 low-risk CABG patients between 1998 and 2000. Five years after their surgery, surviving patients were invited for a follow-up assessment.
INTERVENTION: Patients were randomly assigned to receive either off-pump (n = 142) or on-pump (n = 139) CABG surgery.
MAIN OUTCOME MEASURE: The primary measure was cognitive status 5 years after surgery, which was determined by a psychologist blinded to treatment allocation who administered 10 standardized validated neuropsychological tests. Secondary measures were occurrence of cardiovascular events (all-cause mortality, stroke, myocardial infarction, and coronary reintervention), anginal status, and quality of life.
RESULTS: After 5 years, 130 patients were alive in each group. Cognitive outcomes could be determined in 123 and 117 patients in the off-pump and on-pump groups, respectively. When using a standard definition of cognitive decline (20% decline in performance in 20% of the neuropsychological test variables), 62 (50.4%) of 123 in the off-pump group and 59 (50.4%) of 117 in the on-pump group had cognitive decline (absolute difference, 0%; 95% confidence interval [CI], -12.7% to 12.6%; P>.99). When a more conservative definition of cognitive decline was used, 41 (33.3%) in the off-pump group and 41 (35.0%) in the on-pump group had cognitive decline (absolute difference, -1.7%; 95% CI, -13.7% to 10.3%; P = .79). Thirty off-pump patients (21.1%) and 25 on-pump patients (18.0%) experienced a cardiovascular event (absolute difference, 3.1%; 95% CI, -6.1% to 12.4%; P = .55). No differences were observed in anginal status or quality of life.
CONCLUSION: In low-risk patients undergoing CABG surgery, avoiding the use of cardiopulmonary bypass had no effect on 5-year cognitive or cardiac outcomes.
Diederik van Dijk; Monique Spoor; Ron Hijman; Hendrik M Nathoe; Cornelius Borst; Erik W L Jansen; Diederick E Grobbee; Peter P T de Jaegere; Cor J Kalkman;
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  JAMA     Volume:  297     ISSN:  1538-3598     ISO Abbreviation:  JAMA     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-21     Completed Date:  2007-02-23     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  United States    
Other Details:
Languages:  eng     Pagination:  701-8     Citation Subset:  AIM; IM    
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MeSH Terms
Coronary Artery Bypass*
Coronary Artery Bypass, Off-Pump*
Follow-Up Studies
Middle Aged
Neuropsychological Tests
Quality of Life
Treatment Outcome

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