Document Detail

Cognitive behavioural therapy for major psychiatric disorder: does it really work? A meta-analytical review of well-controlled trials.
MedLine Citation:
PMID:  19476688     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although cognitive behavioural therapy (CBT) is claimed to be effective in schizophrenia, major depression and bipolar disorder, there have been negative findings in well-conducted studies and meta-analyses have not fully considered the potential influence of blindness or the use of control interventions. METHOD: We pooled data from published trials of CBT in schizophrenia, major depression and bipolar disorder that used controls for non-specific effects of intervention. Trials of effectiveness against relapse were also pooled, including those that compared CBT to treatment as usual (TAU). Blinding was examined as a moderating factor. RESULTS: CBT was not effective in reducing symptoms in schizophrenia or in preventing relapse. CBT was effective in reducing symptoms in major depression, although the effect size was small, and in reducing relapse. CBT was ineffective in reducing relapse in bipolar disorder. CONCLUSIONS: CBT is no better than non-specific control interventions in the treatment of schizophrenia and does not reduce relapse rates. It is effective in major depression but the size of the effect is small in treatment studies. On present evidence CBT is not an effective treatment strategy for prevention of relapse in bipolar disorder.
D Lynch; K R Laws; P J McKenna
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Publication Detail:
Type:  Comparative Study; Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't     Date:  2009-05-29
Journal Detail:
Title:  Psychological medicine     Volume:  40     ISSN:  1469-8978     ISO Abbreviation:  Psychol Med     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-03     Completed Date:  2010-03-01     Revised Date:  2010-05-05    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  9-24     Citation Subset:  IM    
Stobhill Hospital, Glasgow, UK.
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MeSH Terms
Bipolar Disorder / psychology,  therapy*
Cognitive Therapy / methods*
Controlled Clinical Trials as Topic
Depressive Disorder, Major / psychology,  therapy*
Psychotic Disorders / psychology,  therapy*
Recurrence / prevention & control
Schizophrenia / therapy*
Schizophrenic Psychology*
Treatment Outcome
Comment In:
Psychol Med. 2010 Jun;40(6):1055-6   [PMID:  20158935 ]
Psychol Med. 2010 May;40(5):877-80   [PMID:  19917145 ]
Psychol Med. 2010 Jan;40(1):25-7   [PMID:  19570315 ]

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