| Cognitive, behavioral, and physiological changes in Alzheimer disease patients as a function of incontinence medications. | |
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MedLine Citation:
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PMID: 15845759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Authors evaluated the cognitive, neurophysiologic, and behavioral effects of incontinence medications in patients with Alzheimer disease (AD). METHODS: Nine patients were evaluated, both on and off incontinence medication, for cognitive status, neuropsychiatric status, activities of daily living, and serum anticholinergic level. Caregivers were interviewed to evaluate behavioral status and caregiver burden. RESULTS: Patients showed better performance on specific measures of cognition and behavior when not taking medication for incontinence. A significant, inverse correlation was found between mental status and anticholinergic level. CONCLUSION: Although the sample size was small, the findings suggest that, in patients with AD, incontinence medications with anticholinergic properties may have detrimental effects on mental status and behavior. |
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Authors:
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Rita D Jewart; Joanne Green; Ching-ju Lu; Janet Cellar; Larry E Tune |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry Volume: 13 ISSN: 1064-7481 ISO Abbreviation: Am J Geriatr Psychiatry Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-04-22 Completed Date: 2005-09-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9309609 Medline TA: Am J Geriatr Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 324-8 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Emory University School of Medicine, Wesley Woods Health Center, 1841 Clifton Road NE, Atlanta, GA 30329, USA. rjewart@emory.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Activities of Daily Living Alzheimer Disease / epidemiology* Benzhydryl Compounds / adverse effects*, therapeutic use Caregivers Cholinergic Antagonists / blood Cognition Disorders / diagnosis, epidemiology* Cresols / adverse effects*, therapeutic use Cross-Over Studies Humans Memory Disorders / diagnosis, epidemiology Mental Disorders / diagnosis, epidemiology* Muscarinic Antagonists / adverse effects*, blood, therapeutic use Neuropsychological Tests Phenylpropanolamine / adverse effects*, therapeutic use Psychometrics Questionnaires Single-Blind Method Urinary Incontinence / drug therapy*, epidemiology* Wakefulness |
| Chemical | |
Reg. No./Substance:
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0/Benzhydryl Compounds; 0/Cholinergic Antagonists; 0/Cresols; 0/Muscarinic Antagonists; 124937-51-5/tolterodine; 14838-15-4/Phenylpropanolamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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