| Cognitive and behavioral assessment in dogs and pet food market applications. | |
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MedLine Citation:
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PMID: 15795054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A multi-disciplinary program was developed to assess the efficacy of antioxidant inclusion in a canine pet food on cognitive decline in aged beagles. A systematic approach to development of the food was used prior to beginning the cognitive studies. Comprehensive evaluation of antioxidant ingredients included assessments of commodities with naturally occurring antioxidants and synthetic antioxidants not commonly utilized, or at different concentrations than what was commonly utilized, in commercial pet foods. Studies were conducted to insure stability through processing, absorption from the gastrointestinal tract, safety, and tests for potential antioxidant biological benefit by ex vivo tests. Testing of the antioxidant-fortified food in aged beagles slowed the rate of cognitive decline in aged dogs. In addition, environmental enrichment also slowed the rate of cognitive decline. Importantly, the combination of dietary antioxidants and environmental enrichment was synergistic and resulted in the least amount of cognitive decline over the 30-month study period. Finally, a clinical study showed that antioxidant fortified food improved age-related behavioral changes in older pet dogs at in-home situations. |
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Authors:
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Steven C Zicker |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Progress in neuro-psychopharmacology & biological psychiatry Volume: 29 ISSN: 0278-5846 ISO Abbreviation: Prog. Neuropsychopharmacol. Biol. Psychiatry Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-03-29 Completed Date: 2005-06-17 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8211617 Medline TA: Prog Neuropsychopharmacol Biol Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 455-9 Citation Subset: IM |
Affiliation:
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Hill's Pet Nutrition, Inc., Science and Technology Center, PO Box 1658, Topeka, KS 66601-1658, USA. Steven_Zicker@hillspet.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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drug effects Animals Antioxidants / economics*, pharmacology Behavior, Animal / physiology* Cognition / physiology* Dogs Dose-Response Relationship, Drug Food, Fortified* Health Food Learning / drug effects, physiology Marketing* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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