Document Detail

Cognitive and behavioral assessment in dogs and pet food market applications.
MedLine Citation:
PMID:  15795054     Owner:  NLM     Status:  MEDLINE    
A multi-disciplinary program was developed to assess the efficacy of antioxidant inclusion in a canine pet food on cognitive decline in aged beagles. A systematic approach to development of the food was used prior to beginning the cognitive studies. Comprehensive evaluation of antioxidant ingredients included assessments of commodities with naturally occurring antioxidants and synthetic antioxidants not commonly utilized, or at different concentrations than what was commonly utilized, in commercial pet foods. Studies were conducted to insure stability through processing, absorption from the gastrointestinal tract, safety, and tests for potential antioxidant biological benefit by ex vivo tests. Testing of the antioxidant-fortified food in aged beagles slowed the rate of cognitive decline in aged dogs. In addition, environmental enrichment also slowed the rate of cognitive decline. Importantly, the combination of dietary antioxidants and environmental enrichment was synergistic and resulted in the least amount of cognitive decline over the 30-month study period. Finally, a clinical study showed that antioxidant fortified food improved age-related behavioral changes in older pet dogs at in-home situations.
Steven C Zicker
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  29     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-29     Completed Date:  2005-06-17     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  455-9     Citation Subset:  IM    
Hill's Pet Nutrition, Inc., Science and Technology Center, PO Box 1658, Topeka, KS 66601-1658, USA.
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MeSH Terms
Aging / drug effects
Antioxidants / economics*,  pharmacology
Behavior, Animal / physiology*
Cognition / physiology*
Dose-Response Relationship, Drug
Food, Fortified*
Health Food
Learning / drug effects,  physiology
Reg. No./Substance:

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