Document Detail


Cognitive aging: a common decline of episodic recollection and spatial memory in rats.
MedLine Citation:
PMID:  18768688     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In humans, recognition memory declines with aging, and this impairment is characterized by a selective loss in recollection of previously studied items contrasted with relative sparing of familiarity for items in the study list. Rodent models of cognitive aging have focused on water maze learning and have demonstrated an age-associated loss in spatial, but not cued memory. The current study examined odor recognition memory in young and aged rats and compared performance in recognition with that in water maze learning. In the recognition task, young rats used both recollection and familiarity. In contrast, the aged rats showed a selective loss of recollection and relative sparing of familiarity, similar to the effects of hippocampal damage. Furthermore, performance on the recall component, but not the familiarity component, of recognition was correlated with spatial memory and recollection was poorer in aged rats that were also impaired in spatial memory. These results extend the pattern of impairment in recollection and relative sparing of familiarity observed in human cognitive aging to rats, and suggest a common age-related impairment in both spatial learning and the recollective component of nonspatial recognition memory.
Authors:
R Jonathan Robitsek; Norbert J Fortin; Ming Teng Koh; Michela Gallagher; Howard Eichenbaum
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  28     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-04     Completed Date:  2008-10-16     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8945-54     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aging / physiology*
Analysis of Variance
Animals
Behavior, Animal
Male
Maze Learning / physiology
Memory Disorders / physiopathology*
Mental Recall / physiology*
Neuropsychological Tests
Odors
ROC Curve
Rats
Rats, Long-Evans
Recognition (Psychology) / physiology
Regression Analysis
Spatial Behavior / physiology*
Grant Support
ID/Acronym/Agency:
AG09973/AG/NIA NIH HHS; R01 MH052090/MH/NIMH NIH HHS; R01 MH052090-13/MH/NIMH NIH HHS
Comments/Corrections

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