Document Detail

Cognitive impairment occurs in children and adolescents with multiple sclerosis: results from a United States network.
MedLine Citation:
PMID:  23155206     Owner:  NLM     Status:  MEDLINE    
In the largest sample studied to date, we measured cognitive functioning in children and adolescents with pediatric multiple sclerosis (n = 187) as well as those with clinically isolated syndrome (n = 44). Participants were consecutively enrolled from six United States Pediatric Multiple Sclerosis Centers of Excellence. Participants had a mean of 14.8 ± 2.6 years of age and an average disease duration of 1.9 ± 2.2 years. A total of 65 (35%) children with multiple sclerosis and 8 (18%) with clinically isolated syndrome met criteria for cognitive impairment. The most frequent areas involved were fine motor coordination (54%), visuomotor integration (50%), and speeded information processing (35%). A diagnosis of multiple sclerosis (odds ratio = 3.60, confidence interval = 1.07, 12.36, P = .04) and overall neurologic disability (odds ratio = 1.47, confidence interval = 1.10, 2.10, P = .03) were the only independent predictors of cognitive impairment. Cognitive impairment may occur early in these patients, and prompt recognition is critical for their care.
Laura Julian; Dana Serafin; Leigh Charvet; Joseph Ackerson; Ralph Benedict; Ellen Braaten; Tanya Brown; Ellen O'Donnell; Joy Parrish; Thomas Preston; Michael Zaccariello; Anita Belman; Tanuja Chitnis; Mark Gorman; Jayne Ness; Marc Patterson; Moses Rodriguez; Emmanuelle Waubant; Bianca Weinstock-Guttman; Ann Yeh; Lauren B Krupp;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-15
Journal Detail:
Title:  Journal of child neurology     Volume:  28     ISSN:  1708-8283     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-24     Completed Date:  2013-06-04     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  102-7     Citation Subset:  IM    
Department of Neuropsychology, University of California San Francisco, San Francisco, CA, USA.
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MeSH Terms
Cognition Disorders / diagnosis,  etiology*
Cross-Sectional Studies
Logistic Models
Multiple Sclerosis / complications*
Nervous System Diseases / etiology
Neuropsychological Tests
United States
Grant Support

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