Document Detail


Cognitive Function in an Elderly Population: Interaction Between Vitamin B12 Status, Depression, and Apolipoprotein E {varepsilon}4: The Hordaland Homocysteine Study.
MedLine Citation:
PMID:  23213264     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ObjectiveTo investigate the cross-sectional relation between metabolic markers of vitamin B(12) status and cognitive performance, and possible effect modification by the presence of depression and apolipoprotein E (ApoE) ε4.MethodsThis is a population-based study of 1935 participants, aged 71 to 74 years, from Norway. Participants were administered a cognitive test battery, and vitamin B(12) status was assessed by measurements of plasma vitamin B(12), holotranscobalamin (holoTC), methylmalonic acid (MMA), and total homocysteine.ResultsThe geometric mean (95% confidence interval) for vitamin B(12) was 348 pM (341-354), whereas 5.9% of participants had vitamin B(12) levels lower than 200 pM. In linear regression analyses, holoTC (p = .039) and the holoTC/vitamin B(12) ratio (p = .013) were positively related, whereas MMA (p = .010) was inversely related, to global cognition, after adjustment for sex, education, ApoE status, plasma creatinine, and history of diabetes, cardiovascular disease, hypertension, and depression. Among those positive for ApoE ε4, but not among those without the ε4 allele, plasma vitamin B(12) was positively associated with global cognition (p = .015), whereas MMA was inversely related to global cognition (p = .036) and executive function (p = .014). In participants with depression, MMA was inversely associated with global cognition (p < .001) and episodic memory (p = .001).ConclusionsAmong the well-nourished elderly, low vitamin B(12) status is associated with cognitive deficit, particularly in those with the ApoE ε4 allele or with depression.
Authors:
Anna Vogiatzoglou; A David Smith; Eha Nurk; Christian A Drevon; Per M Ueland; Stein E Vollset; Harald A Nygaard; Knut Engedal; Grethe S Tell; Helga Refsum
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-4
Journal Detail:
Title:  Psychosomatic medicine     Volume:  -     ISSN:  1534-7796     ISO Abbreviation:  Psychosom Med     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
OPTIMA (A.V., A.D.S., H.R.), Department of Pharmacology, University of Oxford, Oxford, UK; Department of Surveillance and Evaluation (E.N.), National Institute for Health Development, Tallinn, Estonia; Institute of Basic Medical Sciences (A.V., E.N., C.A.D., H.R.), Department of Nutrition, Faculty of Medicine, University of Oslo, Oslo; Section for Pharmacology (P.M.U.), Institute of Medicine, University of Bergen and Haukeland Hospital, Bergen; Department of Public Health and Primary Health Care (S.E.V., H.A.N., G.S.T.), University of Bergen, Bergen; NKS Olaviken Hospital for Old Age Psychiatry (H.A.N.), Erdal; and Norwegian Center for Dementia Research (K.E.), Department of Geriatric Medicine, Ullevål University Hospital, Oslo, Norway.
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