Document Detail

Cognitive function before and after intensity-modulated radiation therapy in patients with nasopharyngeal carcinoma: a prospective study.
MedLine Citation:
PMID:  20044217     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the effects of radiation therapy (RT) on neurocognitive function in patients with nasopharyngeal carcinoma (NPC). METHODS AND MATERIALS: Thirty patients with NPC treated with intensity-modulated RT were included. Dose-volume histograms of the temporal lobes were obtained in every patient. Neurocognitive tests were administered individually to each patient 1 day before initiation of RT and at least 12 months after completion of RT. Cognitive functioning status was evaluated as change in scores over time. RESULTS: Among the total of 30 patients, 23 patients (76.7%) had significantly lower post-RT cognitive functioning scores compared with their pre-RT scores (p = 0.033). The cognitive functioning scores had significantly declined in the domains of short-term memory, language abilities, and list-generating fluency (p = 0.020, 0.023, and 0.001, respectively). Compared with patients with a mean dose to the temporal lobes of 36 Gy or less, patients with a mean dose of greater than 36 Gy had a significantly greater reduction in cognitive functioning scores (p = 0.017). Patients in whom V60 of the temporal lobes (i.e., the percentage of the temporal lobe volume that had received >60 Gy) was greater than 10% also had a greater reduction in cognitive functioning scores than those in whom V60 was 10% or less (p = 0.039). CONCLUSIONS: The results of our study indicated that RT could have deleterious effects on cognitive function in patients with NPC. Efforts should be made to reduce the radiation dose and irradiated volume of temporal lobes without compromising the coverage of target volume.
Kuan-Yin Hsiao; Shyh-An Yeh; Chiung-Chih Chang; Pei-Chien Tsai; Jia-Ming Wu; Jhy-Shyan Gau
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Publication Detail:
Type:  Journal Article     Date:  2010-01-13
Journal Detail:
Title:  International journal of radiation oncology, biology, physics     Volume:  77     ISSN:  1879-355X     ISO Abbreviation:  Int. J. Radiat. Oncol. Biol. Phys.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-06-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603616     Medline TA:  Int J Radiat Oncol Biol Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  722-6     Citation Subset:  IM    
Copyright Information:
(c) 2010 Elsevier Inc. All rights reserved.
Department of Radiation Oncology, E-Da Hospital, Kaohsiung, Taiwan.
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MeSH Terms
Cognition / radiation effects
Cognition Disorders / etiology*
Language Disorders / etiology
Memory Disorders / etiology*
Memory, Short-Term / radiation effects
Middle Aged
Nasopharyngeal Neoplasms / pathology,  radiotherapy*
Prospective Studies
Radiotherapy, Intensity-Modulated / adverse effects*
Temporal Lobe / radiation effects
Tumor Burden

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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