| Cognitive Dysfunction and White Matter Abnormalities in Systemic Lupus Erythematosus. | |
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MedLine Citation:
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PMID: 21338548 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Brain abnormalities have been documented by neuropsychological assessment as well as a variety of neuroimaging techniques in patients with systemic lupus erythematosus (SLE). Conventional neuroimaging in patients with neuropsychiatric disease (NPSLE) typically discloses periventricular white matter (WM) hyperintensities, infarcts, hemorrhages, and cerebral atrophy. In SLE patients with none of these findings, sophisticated neuroimaging techniques have recently supported associations between microstructural WM abnormalities and abnormal attention, executive function, and processing speed. This mild cognitive dysfunction in SLE (MCD-SLE), which may result from early myelinopathy, precedes the more severe cognitive dysfunction of NPSLE, related to more obvious WM and neuronal damage. (JINS, 2011, 17, 1-8). |
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Authors:
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Elizabeth Kozora; Christopher M Filley |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-22 |
Journal Detail:
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Title: Journal of the International Neuropsychological Society : JINS Volume: - ISSN: 1469-7661 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9503760 Medline TA: J Int Neuropsychol Soc Country: - |
Other Details:
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Languages: ENG Pagination: 1-8 Citation Subset: - |
Affiliation:
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1National Jewish Health, Denver, Colorado. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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