| Cognitive and Locomotor/Exploratory Behavior after Chronic Exercise in the Olfactory Bulbectomy Animal Model of Depression. | |
| | |
MedLine Citation:
|
PMID: 21419804 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Despite the evidence that exercise improves cognitive behavior in animal models, little is known about these beneficial effects in animal models of pathology. We examined the effects of activity wheel (AW) running on contextual fear conditioning (CFC) and locomotor/exploratory behavior in the olfactory bulbectomy (OBX) model of depression, which is characterized by hyperactivity and changes in cognitive function. Twenty-four hours after the conditioning session of the CFC protocol, the animals were tested for the conditioned response in a conditioned and a novel context to test for the effects of both AW and OBX on CFC, but also the context specificity of the effect. OBX reduced overall AW running behavior throughout the experiment, but increased locomotor/exploratory behavior during CFC, thus demonstrating a context-dependent effect. OBX animals, however, displayed normal CFC behavior that was context-specific, indicating that aversively-conditioned memory is preserved in this model. AW running increased freezing behavior during the testing session of the CFC protocol in the control animals but only in the conditioned context, supporting the hypothesis that AW running improves cognitive function in a context-specific manner that does not generalize to an animal model of pathology. Blood corticosterone levels were increased in all animals at the conclusion of the testing sessions, but levels were higher in AW compared to sedentary groups indicating an effect of exercise on neuroendocrine function. Given the differential results of AW running on behavior and neuroendocrine function after OBX, further exploration of the beneficial effects of exercise in animal models of neuropathology is warranted. |
| | |
Authors:
|
Van Hoomissen Jacqueline; Kunrath Julie; Dentlinger Renee; Lafrenz Andrew; Krause Mark; Azar Afaf |
Related Documents
:
|
1123934 - Ultrastructural morphometry of the diffusion surface in a case of pulmonary asbestosis. 2225954 - Single lung transplantation for primary pulmonary hypertension. 6267124 - Pulmonary maturation in the hypophysectomised ovine fetus. differential responses to ad... 8574554 - Evaluation of the emphysematous patient. 17446414 - Autonomic cardiovascular and respiratory control during prolonged spaceflights aboard t... 2776744 - Physiological effects of a mouth-borne heat exchanger during heavy exercise in a cold e... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-16 |
Journal Detail:
|
Title: Behavioural brain research Volume: - ISSN: 1872-7549 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
|
Departments of Biology, University of Portland, 5000N Willamette Blvd, Portland OR 97203-5798, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evaluation of two molecular methods for the detection of Yellow fever virus genome.
Next Document: Morphological and neuro-behavioral parallels in the rat model of stroke.