Document Detail


Cognition in perimenopause: the effect of transition stage.
MedLine Citation:
PMID:  23615642     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The aims of this cross-sectional study were to determine if cognitive function differs across stages of reproductive aging and to evaluate whether hormones or menopausal symptoms predict cognition in perimenopause. We hypothesized that women in late menopausal transition and early postmenopause would perform more poorly than those in the late reproductive stage on attention and verbal memory tasks, and that estradiol, depressive symptoms, anxiety symptoms, hot flashes, and sleep disturbance would predict cognitive performance on those tasks.
METHODS: One hundred seventeen middle-aged women enrolled in the Rochester Investigation of Cognition Across Menopause were categorized into late reproductive stage (n = 34), early menopausal transition stage (n = 28), late menopausal transition stage (n = 41), or early postmenopause stage (n = 14) according to criteria from the Stages of Reproductive Aging Workshop +10. We administered a neuropsychological battery assessing six domains of cognition, assessed menopausal symptoms, and measured serum levels of estradiol and follicle-stimulating hormone. Multivariate regressions were conducted to determine the impact of menopausal stage and symptoms on cognition.
RESULTS: Women in the first year of postmenopause performed significantly worse than women in the late reproductive and late menopausal transition stages on measures of verbal learning, verbal memory, and motor function. They also performed significantly worse than women in the late menopausal transition stage on attention/working memory tasks.
CONCLUSIONS: Cognitive function does not change linearly across perimenopause. Decreases in attention/working memory, verbal learning, verbal memory, and fine motor speed may be most evident in the first year after the final menstrual period.
Authors:
Miriam T Weber; Leah H Rubin; Pauline M Maki
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Menopause (New York, N.Y.)     Volume:  20     ISSN:  1530-0374     ISO Abbreviation:  Menopause     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-25     Completed Date:  2014-01-06     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  9433353     Medline TA:  Menopause     Country:  United States    
Other Details:
Languages:  eng     Pagination:  511-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Anxiety / psychology
Attention
Cognition*
Cross-Sectional Studies
Depression / psychology
Estradiol / blood
Executive Function
Female
Follicle Stimulating Hormone / blood
Hot Flashes / psychology
Humans
Learning
Memory
Middle Aged
Neuropsychological Tests
Perimenopause / blood,  psychology*
Postmenopause / blood,  psychology*
Premenopause / blood,  psychology*
Psychomotor Performance
Sleep Disorders, Intrinsic / psychology
Grant Support
ID/Acronym/Agency:
5 M01 RR-00044/RR/NCRR NIH HHS; K12HD055892/HD/NICHD NIH HHS; K23 AG034256/AG/NIA NIH HHS; K23-AG54385484/AG/NIA NIH HHS; P30 AI082151/AI/NIAID NIH HHS; P51 RR000169/RR/NCRR NIH HHS; R03 AG027844/AG/NIA NIH HHS; R03-AG027844/AG/NIA NIH HHS; T32-NS07338/NS/NINDS NIH HHS; UL1 RR024160/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
4TI98Z838E/Estradiol; 9002-68-0/Follicle Stimulating Hormone
Comments/Corrections
Comment In:
Menopause. 2013 Jun;20(6):710-1   [PMID:  23652033 ]
Menopause. 2013 Jun;20(6):710   [PMID:  23858553 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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