| Cognition in multiple sclerosis: relevance of lesions, brain atrophy and proton MR spectroscopy. | |
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MedLine Citation:
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PMID: 20635111 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The overall burden of brain MRI-visible lesions does not fully account for cognitive impairment in multiple sclerosis (MS). Several MRI studies have highlighted the importance of brain damage in the normal-appearing brain tissue. Brain atrophy (global, cortical, white and deep grey matter) is related to cognitive deficits in MS patients and this holds true since the earliest disease stages. Non-conventional MRI techniques such as proton MR spectroscopy have related metabolic changes in specific brain areas to specific cognitive deficits. Overall, data provided by MRI support the notion that cognitive disturbances need to be considered for a more complete clinical characterisation of patients with MS, including those with "benign" MS. |
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Authors:
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Antonio Giorgio; Nicola De Stefano |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology Volume: 31 ISSN: 1590-3478 ISO Abbreviation: Neurol. Sci. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100959175 Medline TA: Neurol Sci Country: Italy |
Other Details:
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Languages: eng Pagination: S245-8 Citation Subset: IM |
Affiliation:
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Department of Neurological and Behavioural Sciences, University of Siena, Siena, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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