| Cognition, MRS neurometabolites, and MRI volumetrics in non-neuropsychiatric systemic lupus erythematosus: preliminary data. | |
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MedLine Citation:
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PMID: 16175019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To correlate cognitive dysfunction with structural and neurometabolic brain findings in patients with non-neuropsychiatric systemic lupus erythematosus (non-NPSLE). BACKGROUND: Over 25% of non-NPSLE patients have cognitive dysfunction, but the cerebral basis of this observation is not well understood. METHOD: Seven patients with non-NPSLE and seven control subjects were given a series of neuropsychological tests and neuroimaging with magnetic resonance imaging and magnetic resonance spectroscopy. Analyses of cognitive function and structural and neurometabolic measures of the brain were performed. RESULTS: Compared with controls, the non-NPSLE patients were significantly impaired on a global cognitive impairment index (CII). No significant differences between the groups were found in choline/creatine (Ch/Cr), N-acetylaspartic acid/Cr, or hippocampal volumes. Ch/Cr was highly associated with CII across the sample. CONCLUSIONS: This is the first study to correlate cognitive impairment with an increase in Ch/Cr ratio among patients with SLE. These results, although preliminary, suggest that changes in cerebral white matter may be important in determining the subtle cognitive impairment that may occur in patients with SLE, even in the absence of neuropsychiatric symptoms. |
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Authors:
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Elizabeth Kozora; David B Arciniegas; Christopher M Filley; Misoo C Ellison; Sterling G West; Mark S Brown; Jack H Simon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology Volume: 18 ISSN: 1543-3633 ISO Abbreviation: Cogn Behav Neurol Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-09-21 Completed Date: 2005-12-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101167278 Medline TA: Cogn Behav Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 159-62 Citation Subset: IM |
Affiliation:
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National Jewish Medical and Research Center, Denver, Colorado 80206, USA. Kozorae@njc.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aspartic Acid / analogs & derivatives, blood Attention / physiology Brain / pathology Brain Chemistry / physiology Choline / blood Cognition Disorders / etiology, pathology*, psychology* Female Frontal Lobe / pathology Hippocampus / pathology Humans Language Lupus Erythematosus, Systemic / complications, pathology*, psychology* Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Memory / physiology Mental Processes / physiology Middle Aged Neuropsychological Tests Psychomotor Performance / physiology Verbal Behavior / physiology |
| Chemical | |
Reg. No./Substance:
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56-84-8/Aspartic Acid; 62-49-7/Choline; 997-55-7/N-acetylaspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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