Document Detail


Cognition, MRS neurometabolites, and MRI volumetrics in non-neuropsychiatric systemic lupus erythematosus: preliminary data.
MedLine Citation:
PMID:  16175019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To correlate cognitive dysfunction with structural and neurometabolic brain findings in patients with non-neuropsychiatric systemic lupus erythematosus (non-NPSLE). BACKGROUND: Over 25% of non-NPSLE patients have cognitive dysfunction, but the cerebral basis of this observation is not well understood. METHOD: Seven patients with non-NPSLE and seven control subjects were given a series of neuropsychological tests and neuroimaging with magnetic resonance imaging and magnetic resonance spectroscopy. Analyses of cognitive function and structural and neurometabolic measures of the brain were performed. RESULTS: Compared with controls, the non-NPSLE patients were significantly impaired on a global cognitive impairment index (CII). No significant differences between the groups were found in choline/creatine (Ch/Cr), N-acetylaspartic acid/Cr, or hippocampal volumes. Ch/Cr was highly associated with CII across the sample. CONCLUSIONS: This is the first study to correlate cognitive impairment with an increase in Ch/Cr ratio among patients with SLE. These results, although preliminary, suggest that changes in cerebral white matter may be important in determining the subtle cognitive impairment that may occur in patients with SLE, even in the absence of neuropsychiatric symptoms.
Authors:
Elizabeth Kozora; David B Arciniegas; Christopher M Filley; Misoo C Ellison; Sterling G West; Mark S Brown; Jack H Simon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology     Volume:  18     ISSN:  1543-3633     ISO Abbreviation:  Cogn Behav Neurol     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-21     Completed Date:  2005-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101167278     Medline TA:  Cogn Behav Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  159-62     Citation Subset:  IM    
Affiliation:
National Jewish Medical and Research Center, Denver, Colorado 80206, USA. Kozorae@njc.org
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MeSH Terms
Descriptor/Qualifier:
Adult
Aspartic Acid / analogs & derivatives,  blood
Attention / physiology
Brain / pathology
Brain Chemistry / physiology
Choline / blood
Cognition Disorders / etiology,  pathology*,  psychology*
Female
Frontal Lobe / pathology
Hippocampus / pathology
Humans
Language
Lupus Erythematosus, Systemic / complications,  pathology*,  psychology*
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Memory / physiology
Mental Processes / physiology
Middle Aged
Neuropsychological Tests
Psychomotor Performance / physiology
Verbal Behavior / physiology
Chemical
Reg. No./Substance:
56-84-8/Aspartic Acid; 62-49-7/Choline; 997-55-7/N-acetylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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