Document Detail


Cognition and 99Tcm-HMPAO SPECT in Parkinson's disease.
MedLine Citation:
PMID:  1491839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
99Tcm-hexamethylpropyleneamine oxime (HMPAO) single photon emission computed tomography (SPECT) of brain was performed in 43 unselected patients with Parkinson's disease to evaluate whether low cerebral perfusion on SPECT correlated with cognitive impairment in the patients. All patients received neurological, Mini-Mental State Examination and a neuropsychological assessment. Eighteen (41.9%) of the 43 patients were demented. Thirty patients (69.8%) had abnormal SPECT: 17 had perfusion defects in cortical regions, eight in basal ganglia and five in both regions. Of the 22 patients with abnormal cortical perfusion, 15 (68.2%) were demented; only three (14.3%) of the 21 patients without cortical defect were demented (P < 0.01). Twelve of the 15 demented patients had low perfusion in the parietal region alone or in parietal and occipital regions. The cortical perfusion defects, present in 22 (51.2%) Parkinson's patients, are highly correlated with cognitive impairment. The pattern of SPECT abnormality in most demented patients with Parkinson's disease is similar to that seen in Alzheimer's disease, suggesting that the underlying pathophysiology for dementia in patients with Parkinson's disease may be similar to that in Alzheimer's disease.
Authors:
R S Liu; K N Lin; S J Wang; D E Shan; J L Fuh; S H Yeh; H C Liu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  13     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1993-03-04     Completed Date:  1993-03-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  744-8     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, Veterans General Hospital-Taipei, Taiwan, Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cerebrovascular Circulation / physiology
Cognition Disorders / etiology*,  physiopathology,  radionuclide imaging
Dementia / etiology*,  physiopathology,  radionuclide imaging
Female
Humans
Male
Middle Aged
Organotechnetium Compounds / diagnostic use*
Oximes / diagnostic use*
Parkinson Disease / physiopathology,  psychology*,  radionuclide imaging
Technetium Tc 99m Exametazime
Tomography, Emission-Computed, Single-Photon*
Chemical
Reg. No./Substance:
0/Organotechnetium Compounds; 0/Oximes; 100504-35-6/Technetium Tc 99m Exametazime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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