Document Detail

Coffee consumption and risk of breast cancer: an up-to-date meta-analysis.
MedLine Citation:
PMID:  23308117     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This updated meta-analysis was conducted to assess the association between coffee consumption and breast cancer risk.
METHODS: We conducted a systematic search updated July 2012 to identify observational studies providing quantitative estimates for breast cancer risk in relation to coffee consumption. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated using a random-effects model, and generalized least square trend estimation was used to assess dose-response relationships.
RESULTS: A total of 26 studies (16 cohort and 10 case-control studies) on coffee intake with 49497 breast cancer cases were included in the meta-analysis. The pooled RR showed a borderline significant influence of highest coffee consumption (RR = 0.96; 95% CI 0.93-1.00), low-to moderate coffee consumption (RR = 0.99; 95% CI 0.95-1.04), or an increment of 2 cups/day of coffee consumption (RR = 0.98; 95% CI 0.97-1.00) on the risk of breast cancer. In stratified analysis, a significant inverse association was observed in ER-negative subgroup. However, no significant association was noted in the others.
CONCLUSIONS: Our findings suggest that increased coffee intake is not associated with a significantly reduced risk of breast cancer, but we observe an inverse association in ER-negative subgroup analysis. More large studies are needed to determine subgroups to obtain more valuable data on coffee drinking and breast cancer risk.
Xiu Juan Li; Zhao Jun Ren; Jian Wei Qin; Jian Hua Zhao; Jin Hai Tang; Ming Hua Ji; Jian Zhong Wu
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't     Date:  2013-01-04
Journal Detail:
Title:  PloS one     Volume:  8     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-11     Completed Date:  2013-07-01     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e52681     Citation Subset:  IM    
Department of Oncology, Xuzhou Medical College, Xuzhou, People's Republic of China.
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MeSH Terms
Breast Neoplasms / etiology*
Case-Control Studies
Cohort Studies
Receptors, Estrogen / analysis
Risk Factors
Reg. No./Substance:
0/Coffee; 0/Receptors, Estrogen

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