| Coexpression of serotonin and nitric oxide in the raphe complex: cortical versus subcortical circuit. | |
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MedLine Citation:
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PMID: 20734426 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several lines of evidence have implicated a direct reciprocal interaction between serotonin and nitric oxide (NO). The goal of this investigation was, therefore, to examine the coexpression of tryptophan hydroxylase (TPH; the rate limiting enzyme for the synthesis of serotonin) and neuronal NO synthase (nNOS) in the ascending cortical projecting raphe nuclei (B6-B9 subgroups), when compared with the descending spinal cord projecting raphe nuclei (B1-B3 subgroups). Our data demonstrated that: (1) a significant number of raphe-cortical projecting neurons was identified not only in the midline subgroup of dorsal raphe (B6, 7) but also in the median raphe (B8), as well as in the supralemniscal nucleus (B9); (2) serotonergic cortical projecting neurons from these three raphe nuclei exhibited a high (>80%) percentage of coexpression with nNOS immunoreactivity; (3) similarly, serotonin transporter immunoreactive fibers in the medial prefrontal cortex were also double-labeled with nNOS immunoreactivity; (4) in contrast, the descending spinal cord projecting raphe nuclei revealed only TPH but not nNOS immunoreactivity. Our present findings suggest the existence of a direct interaction between serotonin and NO in the ascending cortical projecting raphe system. In contrast, a different strategy appears to operate the descending spinal cord projecting raphe system. |
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Authors:
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Yuefeng Lu; Kimberly L Simpson; Kristin J Weaver; Rick C S Lin |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Anatomical record (Hoboken, N.J. : 2007) Volume: 293 ISSN: 1932-8494 ISO Abbreviation: Anat Rec (Hoboken) Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-01 Completed Date: 2011-02-10 Revised Date: 2011-02-21 |
Medline Journal Info:
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Nlm Unique ID: 101292775 Medline TA: Anat Rec (Hoboken) Country: United States |
Other Details:
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Languages: eng Pagination: 1954-65 Citation Subset: IM |
Affiliation:
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Department of Biology, Tougaloo College, Tougaloo, Mississippi, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Neurons / cytology, metabolism Nitric Oxide / metabolism* Nitric Oxide Synthase / metabolism Prefrontal Cortex / cytology, metabolism* Raphe Nuclei / cytology, metabolism* Rats Rats, Long-Evans Serotonin / metabolism* Tryptophan Hydroxylase / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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MH084194/MH/NIMH NIH HHS; R01 MH084194-04/MH/NIMH NIH HHS; RR017701/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 50-67-9/Serotonin; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.14.16.4/Tryptophan Hydroxylase |
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